The characteristics of remnant lipoproteins in the fasting and postprandial plasma
The characteristics of remnant lipoproteins in the fasting and postprandial plasma
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空腹和餐后血浆中残余脂蛋白的特征
DOI：
10.1016/j.cca.2012.02.026
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发表时间：
2012
期刊：
影响因子：
5
通讯作者：
Nakajima K
中科院分区：
文献类型：
--
作者：
Okuhashi Y;Itoh M;Nara N;Tohda S;安井裕之 編著;Nakajima K
背景：在空腹血浆中，残余样脂蛋白颗粒（RLP）已通过胆固醇作为RLP-C测量用于CHD风险评估。方法测定健康体检者和口服脂肪负荷志愿者空腹及餐后血浆中RLP-TG和RLP-C的浓度。同时测定TC、TG、HDL-C、LDL-C、apoB-100、apoB-48、RLP apoB-100和RLP apoB-48。TG浓度<150 mg/dl的代谢综合征患者RLP-TG和RLP-C高于临界值的患病率显著高于对照组。在TG浓度> 80 mg/dl的病例中，口服脂肪负荷后血浆RLP-TG显著增加至> 20 mg/dl。结论：健康志愿者餐后血浆中RLP-TG和RLP-C在TG浓度> 80 mg/dl时显著升高，超过临界值。RLP apoB 100，而不是RLP apoB 48，增加显著时，血浆TG增加后，口服脂肪负荷，尽管血浆apoB 48的增加。结果表明，餐后血浆中增加的主要脂蛋白是VLDL残余物，而不是CM残余物。
BACKGROUNDRemnant-like lipoprotein particles (RLP) have been measured by cholesterol as RLP-C for CHD risk assessment in the fasting plasma. However, RLP-triglyceride (TG) is a better marker of the characteristics of remnant lipoproteins in the postprandial plasma, especially in plasma with TG concentrations <150mg/dl.METHODThe RLP-TG and RLP-C concentrations in subjects undergoing a health check-up and in volunteers receiving an oral fat load were determined in the fasting and postprandial plasma. TC, TG, HDL-C, LDL-C, apoB 100, apoB48, RLP apoB-100 and RLP apoB48 were also determined.RESULTSWhen fasting TG concentrations were <150mg/dl, the 95th percentile of RLP-TG was 20mg/dl and the RLP-C 7.5mg/dl in healthy subjects. The prevalence of RLP-TG and RLP-C above the cut-off values with a TG concentration <150mg/dl was significantly higher in the metabolic syndrome cases than in the controls. RLP-TG increased significantly in plasma to >20mg/dl after an oral fat load in cases with TG concentrations >80mg/dl. Further, RLP apoB100, but not RLP apoB48 was highly correlated with the increase of TG in the postprandial plasma.CONCLUSIONRLP-TG and RLP-C were increased significantly above the cut-off values in the postprandial plasma in healthy volunteers from a TG concentration >80mg/dl. RLP apoB100, but not RLP apoB48, increased significantly when the plasma TG increased after an oral fat load despite the increase of plasma apoB48. The results show that the major lipoproteins which were increased in postprandial plasma were VLDL remnants, not CM remnants.