Correction of positron emission tomography data for cerebral atrophy.
Correction of positron emission tomography data for cerebral atrophy.
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脑萎缩正电子发射断层扫描数据的校正。
DOI：
10.1038/jcbfm.1986.14
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Raichle,ME
中科院分区：
文献类型：
--
作者：
Herscovitch,P;Auchus,AP;Gado,M;Chi,D;Raichle,ME
由于正电子发射断层扫描(PET)提供的是单位体积的颅内内容物测量，因此这些测量可能会受到在进行测量的体积中包含代谢不活跃的脑脊液间隙的影响。因此，在正常衰老和痴呆症中，脑血流和代谢的PET测量可能会人为地降低，这两者都与显著的脑萎缩有关。我们描述了一种方法，通过使用定量X射线计算机断层扫描获得的脑脊液间隙体积的测量来校正在几个断层切片上平均的整体PET数据，以诊断脑萎缩。通过对正常年轻人、正常老年人和痴呆受试者的脑血流和氧代谢的PET测量，证明了进行这种校正的重要性。
Because positron emission tomography (PET) provides measurements per unit volume of intracranial contents, these measurements may be affected by the inclusion of metabolically inactive CSF spaces in the volume in which they are made. Thus, PET measurements of CBF and metabolism may be artifactually lowered in normal aging and dementia, which are both associated with significant brain atrophy. We describe a method to correct global PET data, averaged over several tomographic slices, for cerebral atrophy by using measurements of CSF space volume obtained with quantitative x-ray computed tomography. The importance of making such a correction is demonstrated using PET measurements of CBF and oxygen metabolism obtained in normal young, normal elderly, and demented subjects.