Steeper Slope of Age-Related Changes in White Matter Microstructure and Processing Speed in Bipolar Disorder.
Steeper Slope of Age-Related Changes in White Matter Microstructure and Processing Speed in Bipolar Disorder.
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DOI：
10.1016/j.jagp.2017.02.014
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Eyler LT
中科院分区：
文献类型：
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作者：
Dev SI;Nguyen TT;McKenna BS;Sutherland AN;Bartsch H;Theilmann RJ;Eyler LT
双相情感障碍(BD)与白质(WM)完整性受损和处理速度(PS)缺陷有关。然而，很少有研究调查年龄与WM结构和认知的关系，以了解大脑健康在一生中可能发生的变化。这项调查探索了BD和健康对照(HC)参与者是否表现出与WM和认知的年龄相关的不同关联，这可能暗示大脑和认知老化的加速。横断面研究。加州大学圣地亚哥分校和退伍军人管理局圣地亚哥医疗保健系统。33例BD患者和38例HC患者。获取扩散张量成像作为WM完整性的测量，并利用约翰霍普金斯大学概率图谱提取特定区域的分数各向异性(FA)。采用Delis-Kaplan执行功能系统连线测验中的数字和字母顺序条件评估PS。与HC组相比，BD参与者表现出较慢的PS，但组间FA没有发现差异。多元线性回归显示右侧钩束、左侧扣带的海马区和PS之间存在显著的年龄相关性，只有BD组年龄越大，FA值越低，PS越慢。在计入钩状FA后，年龄和PS之间的关系没有显著变化，这表明观察到的年龄关联是独立发生的。这些结果通过确定脑健康的标记物来证明BD与年龄的不同关联，从而为未来加速衰老假说的研究提供支持。
Bipolar disorder (BD) is associated with compromised white matter (WM) integrity and deficits in processing speed (PS). However, few studies have investigated age relationships with WM structure and cognition to understand possible changes in brain health over the lifespan. This investigation explored whether BD and healthy comparison (HC) participants exhibited differential age-related associations with WM and cognition, which may be suggestive of accelerated brain and cognitive aging. Cross-sectional study. University of California San Diego and the Veterans Administration San Diego Healthcare System. 33 euthymic BD and 38 HC participants. Diffusion tensor imaging was acquired as a measure of WM integrity, and tract-specific fractional anisotropy (FA) was extracted utilizing the Johns Hopkins University probability atlas. PS was assessed with the Number and Letter Sequencing conditions of the Delis-Kaplan Executive Function System Trail Making Test. BD participants demonstrated slower PS compared to the HC group, but no group differences were found in FA across tracts. Multiple linear regressions revealed a significant group-by-age interaction for the right uncinate fasciculus, the left hippocampal portion of the cingulum and for PS, such that older age was associated with lower FA values and slower PS in the BD group only. The relationship between age and PS did not significantly change after accounting for uncinate FA, suggesting that the observed age associations occur independently. Results provide support toward future study of the accelerated aging hypothesis by identifying markers of brain health that demonstrate a differential age association in BD.