Human C-reactive protein and the metabolic syndrome.
Human C-reactive protein and the metabolic syndrome.
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DOI：
10.1097/mol.0b013e32832ac03e
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发表时间：
2009-06
影响因子：
4.4
通讯作者：
Jialal I
中科院分区：
文献类型：
--
作者：
Devaraj S;Singh U;Jialal I
低度炎症是代谢综合征（MetS）的特征。C-反应蛋白（CRP）是炎症的最佳生物标志物，也是未来心血管事件的独立预测因子。本文就炎症和高敏C反应蛋白在代谢综合征中的作用作一综述。新兴的实验室和流行病学数据现在将炎症和高敏感性CRP与胰岛素抵抗和肥胖以及MetS的其他特征联系起来。此外，在大型前瞻性研究中，MetS患者高敏CRP水平升高会增加心血管风险。CRP已被证明会损害胰岛素信号传导，并有助于动脉粥样硬化血栓形成。因此，尽管高CRP水平易导致代谢综合征患者心血管风险增加，但需要进一步研究CRP在体内介导血管效应并导致代谢综合征患者心血管事件增加的作用。
Low-grade inflammation is characteristic of the metabolic syndrome (MetS). C-reactive protein (CRP), the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. The purpose of this review is to outline the role of inflammation and high sensitivity CRP in the MetS. Emerging laboratory and epidemiological data now link inflammation and high sensitivity CRP to insulin resistance and adiposity and other features of MetS. Furthermore, in large prospective studies, increased high sensitivity CRP levels in MetS confer greater cardiovascular risk. CRP has been shown to impair insulin signaling and contributes to atherothrombosis. Thus, although a high CRP level predisposes to increased cardiovascular risk in MetS, future investigation is warranted on the in-vivo role of CRP in mediating vascular effects and resulting in increased cardiovascular events in MetS patients.