Receptor tyrosine kinase-dependent neural crest migration in response to differentially localized growth factors.
Receptor tyrosine kinase-dependent neural crest migration in response to differentially localized growth factors.
复制标题
受体酪氨酸激酶依赖性神经嵴迁移响应差异局部生长因子。
DOI：
10.1002/bies.950190411
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Weston,JA
中科院分区：
文献类型：
--
作者：
Wehrle-Haller,B;Weston,JA
不同的神经嵴衍生物如何在脊椎动物胚胎的不同胚胎位置分化是一个有趣的问题。许多尝试已经做了了解特定途径选择的迁移神经嵴细胞的潜在机制。在这篇推测性的综述中，我们基于对胚胎发生过程中受体酪氨酸激酶的表达和活性的最新进展，提出了一种新的调节鸟类和哺乳动物胚胎神经嵴细胞迁移模式的机制。不同亚群的嵴来源的细胞表达特定受体酪氨酸激酶，而居住在迁移分期区。我们假设神经嵴细胞的特定亚群对受体酪氨酸激酶的差异表达使它们能够对胚胎中的局部生长因子配体活性做出反应。因此，神经嵴亚群所采取的迁移途径是由其受体酪氨酸激酶对其同源配体的差异定位的反应决定的。
How different neural crest derivatives differentiate in distinct embryonic locations in the vertebrate embryo is an intriguing issue. Many attempts have been made to understand the underlying mechanism of specific pathway choices made by migrating neural crest cells. In this speculative review we suggest a new mechanism for the regulation of neural crest cell migration patterns in avian and mammalian embryos, based on recent progress in understanding the expression and activity of receptor tyrosine kinases during embryogenesis. Distinct subpopulations of crest‐derived cells express specific receptor tyrosine kinases while residing in a migration staging area. We postulate that the differential expression of receptor tyrosine kinases by specific subpopulations of neural crest cells allows them to respond to localized growth factor ligand activity in the embryo. Thus, the migration pathway taken by neural crest subpopulations is determined by their receptor tyrosine kinase response to the differential localization of their cognate ligand.