SERUM PHOSPHOLIPASE-A2 IN PATIENTS WITH MULTIPLE INJURIES
SERUM PHOSPHOLIPASE-A2 IN PATIENTS WITH MULTIPLE INJURIES
复制标题
DOI：
10.1097/00005373-199010000-00015
复制
发表时间：
1990-10-01
影响因子：
--
通讯作者：
BEGER, HG
中科院分区：
文献类型：
--
作者：
UHL, W;BUCHLER, M;BEGER, HG
测定了12例多发性损伤患者（损伤严重程度评分中位数：41）血清样本中的催化磷脂酶A2活性（CA-PLA 2）和免疫反应性胰腺PLA 2（IR-PLA 2）浓度。所有患者CA-PLA 2均升高，CA-PLA 2升高程度与死亡率和肺功能损害呈正相关。9例多发伤患者血清中IR-PLA 2值略有升高。在这9例患者中，8例有额外的钝性腹部创伤。另一方面，未发现IR-PLA 2和CA-PLA 2值之间的关系。这一发现得到了用抗人胰腺PLA 2的抗血清进行的免疫吸附实验的证实，该实验表明IR-PLA 2血清水平的增加与CA-PLA 2值的增加无关。结果表明，多发性损伤患者的血清中存在至少两种免疫学不同的磷脂酶A2酶。
Catalytic phospholipase A2 activity (CA-PLA2) and the concentration of immunoreactive pancreatic PLA2 (IR-PLA2) were measured in serum samples from 12 patients with multiple injuries (median Injury Severity Score: 41). CA-PLA2 was increased in all patients and positive correlations were found between the extent of the increase of CA-PLA2, mortality, and impairment of pulmonary function. IR-PLA2 values were slightly increased in the serum of nine patients with multiple injuries. Of these nine patients, eight had an additional blunt abdominal trauma. On the other hand, no relationship was found between IR-PLA2 and CA-PLA2 values. This finding was confirmed by immunoadsorption experiments with an antiserum to human pancreatic PLA2, which demonstrated that the increased serum levels of IR-PLA2 were not responsible for the increased CA-PLA2 values. The results suggest the existence of at least two immunologically different phospholipase A2 enzymes in sera of patients with multiple injuries.