The effect of a six-month exercise program on very low-density lipoprotein apolipoprotein B secretion in type 2 diabetes
The effect of a six-month exercise program on very low-density lipoprotein apolipoprotein B secretion in type 2 diabetes
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DOI：
10.1210/jc.2003-031036
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发表时间：
2004-02-01
影响因子：
5.8
通讯作者：
Umpleby, AM
中科院分区：
文献类型：
--
作者：
Alam, S;Stolinski, M;Umpleby, AM
有氧运动可以改善2型糖尿病的血脂异常和胰岛素抵抗。观察了6个月有监督运动对2型糖尿病患者极低密度脂蛋白（VLDL）载脂蛋白B代谢的影响。中度肥胖患者（n = 18）被随机分为监督（n = 9）和非监督（n = 9）运动组。所有患者都接受了训练课程和个人锻炼计划，并要求每周在70%最大摄氧量下锻炼4次，持续6个月。监督组的患者每周接受一次运动训练。在6个月的运动计划之前和之后，通过输注1-（13）C亮氨酸来测量VLDL载脂蛋白（apo）B代谢，在监督下运动6个月导致组内血红蛋白A1 c百分比显著降低（P < 0.001）、体脂（P < 0.004）、非酯化脂肪酸（P < 0.04）和甘油三酯（P < 0.05）以及胰岛素敏感性增加（P < 0.01）。VLDL载脂蛋白B池大小（160.8 +/- 42.6至84.9 +/- 23.2 mg，P < 0.01）和VLDL载脂蛋白B分泌率（11.3 +/- 2.6至5.5 +/- 2.0 mg/kg.d，P < 0.05）降低，分解率无变化。在组间比较中，监督组中VLDL apoB分泌率的降低未达到显著性。这项研究表明，在2型糖尿病患者中，有监督的运动计划减少了VLDL apoB池的大小，这可能是由于VLDL apoB分泌率降低。
The dyslipidemia and insulin resistance of type 2 diabetes can be improved by aerobic exercise. The effect of 6 months supervised exercise on very low-density lipoprotein (VLDL) apolipoprotein B metabolism was investigated in patients with type 2 diabetes. Moderately obese patients (n = 18) were randomized into supervised (n = 9) and unsupervised (n = 9) exercise groups. All patients were given a training session and a personal exercise program and asked to exercise four times per week at 70% maximal oxygen uptake for 6 months. Patients in the supervised group had a weekly session with an exercise trainer. VLDL apolipoprotein (apo) B metabolism was measured with an infusion of 1-(13)C leucine before and after 6 months of the exercise program.Supervised exercise for 6 months resulted in a significant within-group decrease in percent hemoglobin A1c (P < 0.001), body fat (P < 0.004), nonesterified fatty acid (P < 0.04), and triglycerides (P < 0.05) and an increase in insulin sensitivity (P < 0.01). There was a decrease in VLDL apoB pool size (160.8 +/- 42.6 to 84.9 +/- 23.2 mg, P < 0.01) and VLDL apoB secretion rate (11.3 +/- 2.6 to 5.5 +/- 2.0 mg/kg.d, P < 0.05) with no change in fractional catabolic rate. In a between-group comparison, the decrease in VLDL apoB secretion rate in the supervised group did not achieve significance. This study demonstrates that in type 2 diabetes, a supervised exercise program reduces VLDL apoB pool size, which may be due to a decrease in VLDL apoB secretion rate.