Facilitation of postural limb reflexes in spinal rabbits by serotonergic agonist administration, epidural electrical stimulation, and postural training
Facilitation of postural limb reflexes in spinal rabbits by serotonergic agonist administration, epidural electrical stimulation, and postural training
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DOI：
10.1152/jn.00115.2011
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发表时间：
2011-09-01
影响因子：
2.5
通讯作者：
Deliagina, T. G.
中科院分区：
文献类型：
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作者：
Lyalka, V. F.;Hsu, L. -J.;Deliagina, T. G.
Lyalka VF、Hsu LJ、Karayannidou A、Zelenin PV、Orlovsky GN、Deliagina TG。通过给予血清素激动剂、硬膜外电刺激和姿势训练促进脊柱兔的姿势肢体反射。 《神经生理学杂志》106：1341-1354，2011 年。首次发表于 2011 年 6 月 8 日； doi:10.1152/jn.00115.2011.-在四足动物中，胸部区域的脊柱化严重损害了后躯的姿势控制。本研究的目的是通过定期应用不同因素来改善慢性脊柱兔的姿势功能：鞘内注射 5-HT2 激动剂 (+/-)-1-(2,5-二甲氧基-4-碘苯基)-2-氨基丙烷盐酸盐 (DOI)、硬膜外脊髓电刺激 (EES) 和特定姿势训练 (SPT)。这些因素可以单独使用（SPT 组），也可以组合使用（DOI + SPT、EES + SPT 和 DOI + EES + SPT 组）或不使用（对照组）。结果发现，这些组中没有一个在治疗一个月内再次出现针对支撑平台横向倾斜的正常姿势矫正运动。在对照组中，观察到不规则肌电图 (EMG) 反应减少，无论是与倾斜相关的阶段正确还是错误。相比之下，在 DOI + SPT 和 EES + SPT 组中，观察到正确定相 EMG 反应的比例（与对照组相比）逐渐增加了三倍。 DOI + EES + SPT 和 SPT 组的增幅较小。与这些长期影响不同的是，DOI 和 EES 的短期影响很弱或不存在。此外，在 DOI + SPT、EES + SPT、DOI + EES + SPT 和 SPT 组中，对照组特有的倾斜反应中振荡肌电图活动的逐渐发展被延迟。因此，定期应用这三种测试因素及其组合会在孤立的脊柱网络中引起渐进的、持久的塑性变化，从而促进脊柱姿势反射并延缓振荡肌电图活动的发展。然而，促进的反射不足以维持正常的姿势功能。
Lyalka VF, Hsu LJ, Karayannidou A, Zelenin PV, Orlovsky GN, Deliagina TG. Facilitation of postural limb reflexes in spinal rabbits by serotonergic agonist administration, epidural electrical stimulation, and postural training. J Neurophysiol 106: 1341-1354, 2011. First published June 8, 2011; doi:10.1152/jn.00115.2011.-In quadrupeds, spinalization in the thoracic region severely impairs postural control in the hindquarters. The goal of this study was to improve postural functions in chronic spinal rabbits by regular application of different factors: intrathecal injection of the 5-HT2 agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI), epidural electrical spinal cord stimulation (EES), and specific postural training (SPT). The factors were used either alone (SPT group) or in combination (DOI + SPT, EES + SPT, and DOI + EES + SPT groups) or not used (control group). It was found that in none of these groups did normal postural corrective movements in response to lateral tilts of the supporting platform reappear within the month of treatment. In control group, reduced irregular electromyographic (EMG) responses, either correctly or incorrectly phased in relation to tilts, were observed. By contrast, in DOI + SPT and EES + SPT groups, a gradual threefold increase in the proportion of correctly phased EMG responses (compared with control) was observed. The increase was smaller in DOI + EES + SPT and SPT groups. Dissimilarly to these long-term effects, short-term effects of DOI and EES were weak or absent. In addition, gradual development of oscillatory EMG activity in the responses to tilts, characteristic for the control group, was retarded in DOI + SPT, EES + SPT, DOI + EES + SPT, and SPT groups. Thus regular application of the three tested factors and their combinations caused progressive, long-lasting plastic changes in the isolated spinal networks, resulting in the facilitation of spinal postural reflexes and in the retardation of the development of oscillatory EMG activity. The facilitated reflexes, however, were insufficient for normal postural functions.