Practice effects in the prediction of long-term cognitive outcome in three patient samples: A novel prognostic index
Practice effects in the prediction of long-term cognitive outcome in three patient samples: A novel prognostic index
复制标题
DOI：
10.1016/j.acn.2006.08.013
复制
发表时间：
2007-01-01
影响因子：
2.6
通讯作者：
Paulsen, Jane S.
中科院分区：
文献类型：
--
作者：
Duff, Kevin;Beglinger, Leigh J.;Paulsen, Jane S.
练习效应，定义为由于重复接触测试材料而导致的认知测试表现的改善，传统上被视为错误的来源。然而，它们可能为预测认知结果提供有用的信息。目前的研究使用了三个独立的患者样本（患有轻度认知障碍的老年人，HIV阳性的人，患有亨廷顿病的人）来检查练习效果和认知功能之间的关系。在所有三个样本中，在控制了基线认知功能后，练习效果占随访认知评分方差的31-83%。如果这些发现可以在其他神经退行性疾病患者中复制，临床医生和研究人员可能能够开发预测模型，以确定最有可能随着时间的推移表现出持续认知能力下降的个体。利用实践效果数据的能力将增加用于监测个体患者的认知状态的简单、方便且非侵入性的标记。此外，该预后指数可用于为处于进行性神经退行性疾病最早阶段的患者提供干预措施。(c)2006年美国国家神经心理学学会。由爱思唯尔有限公司出版。保留所有权利。
Practice effects, defined as improvements in cognitive test performance due to repeated exposure to the test materials, have traditionally been viewed as sources of error. However, they might provide useful information for predicting cognitive outcome. The current study used three separate patient samples (older adults with mild cognitive impairments, individuals who were HIV+, individuals with Huntington's disease) to examine the relationship between practice effects and cognitive functioning at a later point. Across all three samples, practice effects accounted for as much as 31-83% of the variance in the follow-up cognitive scores, after controlling for baseline cognitive functioning. If these findings can be replicated in other patients with neurodegenerative disorders, clinicians and researchers may be able to develop predictive models to identify the individuals who are most likely to demonstrate continued cognitive decline across time. The ability to utilize practice effects data would add a simple, convenient, and non-invasive marker for monitoring an individual patient's cognitive status. Additionally, this prognostic index could be used to offer interventions to patients who are in the earliest stages of progressive neurodegenerative disorders. (c) 2006 National Academy of Neuropsychology. Published by Elsevier Ltd. All rights reserved.