Criticisms of 'Specific long-term memory traces in primary auditory cortex'
Criticisms of 'Specific long-term memory traces in primary auditory cortex'
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对“初级听觉皮层中特定的长期记忆痕迹”的批评
DOI：
10.1038/nrn1366-c3
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发表时间：
2004
影响因子：
34.7
通讯作者：
Xiaofeng Ma
中科院分区：
文献类型：
--
作者：
N. Suga;Weiqing Ji;Xiaofeng Ma
这些评论与Weinberger 1最近的评论有关。在大棕蝠中，听觉皮层（AC）和下丘的“音调特异性”最佳频率（BF）变化既不是由单独的声刺激（CS）引起的，也不是由单独的腿刺激（US）引起的，而是由成对刺激（CS-US）引起的，即由听觉恐惧条件反射引起的。后向条件反射（US-CS）不会引起这些BF偏移。BF移位特定于条件音（CS）的频率。与丘BF移位不同，皮质BF移位在条件反射终止后增加并达到平台。这种高原持续了很长一段时间2，3，4。这种长期的皮质BF转变是由皮质乙酰胆碱的增加引起的3，4，5。因此，皮层BF移位代表了生理联想记忆。Suga等人提出了一种用于唤起长期皮层BF移位的神经网络2，3。我们的假设指出，小的和短期的音调特定的皮质和丘BF的变化引起的AC，和单独的音调刺激激活的离皮质反馈，和皮质BF的变化是增强和改变成一个长期的转变由基底前脑，这是激活的听觉和体感皮层通过杏仁核引起的皮质乙酰胆碱增加。这一假说或模型不同于Weinberger的模型6，其中CS-US关联发生在多感觉丘脑核团（内侧膝状体/后板内核（MGBm/PIN）的大细胞分裂），MGBm-AC投射引起小的短期皮质BF移位，基底前脑引起的皮质乙酰胆碱增加会增强BF移位并将其变为长期移位，其由MGBm/PIN通过杏仁核激活。
These comments relate to the recent review by Weinberger 1. In the big brown bat,'tone-specific'best frequency (BF) shifts in the auditory cortex (AC) and the inferior colliculus are evoked by neither acoustic stimulation (CS) alone, nor leg-stimulation (US) alone, but by paired stimulation (CS–US), that is, by auditory fear conditioning. Backward conditioning (US–CS) does not evoke these BF shifts. The BF shifts are specific to the frequency of the conditioned tone (the CS). Unlike the collicular BF shift, the cortical BF shift increases and reaches a plateau after the termination of conditioning. This plateau is sustained for a long period of time 2, 3, 4. This long-term cortical BF shift is elicited by an increase in cortical acetylcholine 3, 4, 5. Therefore, the cortical BF shift represents physiological associative memory.A neural network for evoking the long-term cortical BF shift is proposed by Suga and co-workers 2, 3. Our hypothesis states that small and short-term tone-specific cortical and collicular BF shifts are evoked by the AC, and corticofugal feedback activated by tone stimulation alone, and that the cortical BF shift is augmented and changed into a long-term shift by increased cortical acetylcholine elicited by the basal forbrain, which is activated by the auditory and somatosensory cortices through the amygdala. This hypothesis, or model, differs from Weinberger's model 6, in which CS–US association occurs in the multi-sensory thalamic nuclei (magnocellular division of the medial geniculate body/posterior intralaminar nucleus (MGBm/PIN)), the MGBm–AC projection evokes a small short-term cortical BF shift, and this BF shift is augmented and changed into a long-term shift by an increase in cortical acetylecholine elicited by the basal forebrain, which is activated by the MGBm/PIN through the amygdala.
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影响因子：
2.5
作者：
Chowdhury, SA;Suga, N
通讯作者：
Suga, N
DOI：
10.1073/pnas.95.21.12663
发表时间：
1998-10-13
影响因子：
11.1
作者：
Gao, E;Suga, N
通讯作者：
Suga, N
影响因子：
2.5
作者：
Ji, WQ;Gao, EQ;Suga, NB
通讯作者：
Suga, NB
DOI：
10.1073/pnas.97.22.11807
发表时间：
2000-10
影响因子：
11.1
作者：
Nobuo Suga;Enquan Gao;Yunfeng Zhang;Xiaofeng Ma;J. F. Olsen
通讯作者：
Nobuo Suga;Enquan Gao;Yunfeng Zhang;Xiaofeng Ma;J. F. Olsen
影响因子：
2.5
作者：
Ji, WQ;Suga, N
通讯作者：
Suga, N