Molecular structure of (+/-)-7,8,9,10-tetrahydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene determined by x-ray crystallography.
Molecular structure of (+/-)-7,8,9,10-tetrahydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene determined by x-ray crystallography.
复制标题
通过X射线晶体学测定(I-)-7,8,9,10-四羟基-7,8,9,10-四氢苯并(a)芘的分子结构。
作者：
S. Neidle;A. Subbiah;R. Kuroda;C. S. Cooper
The molecular structure of a tetrahydrotetrol that is formed by hydrolysis of (+/-)-7 alpha, 8 beta-dihydroxy-9 beta, 10 beta-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene, has been determined by X-ray crystallographic methods. The relative orientations of the four hydroxyl groups of the racemic tetrahydrotetrol (7 alpha, 8 beta, 9 beta, 10 alpha) indicate that the tetrahydrotetrol was formed by the trans opening of the epoxide ring of the diol-oxide. The hydroxyl groups at positions 7 and 8 adopt a diequatorial conformation, while those at positions 9 and 10 adopt a diaxial conformation. Several other geometric features are discussed.
致癌物引起的 DNA 结构改变。
DOI：
--
发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Hogan,ME;Dattagupta,N;WhitlockJr,JP
通讯作者：
WhitlockJr,JP
7,8-二羟基-9,10-环氧苯并(a)芘与 DNA 的非共价嵌入结合。
DOI：
10.1016/0006-291x(81)90698-7
发表时间：
1981
影响因子：
3.1
作者：
Geacintov,NE;Yoshida,H;Ibanez,V;Harvey,RG
通讯作者：
Harvey,RG