Molecular evolution of immunoglobulin superfamily genes in primates
Molecular evolution of immunoglobulin superfamily genes in primates
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DOI：
10.1007/s00251-011-0519-7
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发表时间：
2011-07-01
期刊：
影响因子：
3.2
通讯作者：
Kimura, Akinori
中科院分区：
文献类型：
--
作者：
Ohtani, Hitoshi;Nakajima, Toshiaki;Kimura, Akinori
免疫球蛋白超家族（IgSF）的基因具有多种细胞活性。本研究通过比较人类、黑猩猩、猩猩、恒河猴和普通狨猴的249个IgSF基因的同源序列，研究了IgSF基因在灵长类动物中的分子进化。为了评估非同义/同义取代比（omega），我们采用了Bn-Bs程序和PAML程序。基于基因本体（Gene Ontology， GO）数据库，将IgSF基因划分为11个功能类。其中，与免疫系统调控密切相关的免疫系统过程（GO: 0002376）、防御反应（GO: 0006952）和多生物过程（GO: 0051704）三个功能类别中的IgSF基因的值要高得多。比其他氧化石墨烯类别的基因更重要。此外，我们估计了的平均值。对于每个灵长类谱系。尽管每个灵长类谱系都有可比较的平均值。在美国，人类血统表现出最低水平。免疫相关基因的价值。此外，11个IgSF基因SIGLEC5、SLAMF6、CD33、CD3E、CEACAM8、CD3G、FCER1A、CD48、CD4、TIM4和FCGR2A在灵长类动物进化过程中处于正选择压力下。对23种灵长类动物的CD3E和CD3G的进一步序列分析表明，CD3E和CD3G的Ig结构域经历了达尔文选择的积极作用。
Genes of the immunoglobulin superfamily (IgSF) have a wide variety of cellular activities. In this study, we investigated molecular evolution of IgSF genes in primates by comparing orthologous sequences of 249 IgSF genes among human, chimpanzee, orangutan, rhesus macaque, and common marmoset. To evaluate the non-synonymous/synonymous substitution ratio (omega), we applied Bn-Bs program and PAML program. IgSF genes were classified into 11 functional categories based on the Gene Ontology (GO) database. Among them, IgSF genes in three functional categories, immune system process (GO: 0002376), defense response (GO: 0006952), and multi-organism process (GO: 0051704), which are tightly linked to the regulation of immune system had much higher values of. than genes in the other GO categories. In addition, we estimated the average values of. for each primate lineage. Although each primate lineage had comparable average values of., the human lineage showed the lowest. value for the immune-related genes. Furthermore, 11 IgSF genes, SIGLEC5, SLAMF6, CD33, CD3E, CEACAM8, CD3G, FCER1A, CD48, CD4, TIM4, and FCGR2A, were implied to have been under positive selective pressure during the course of primate evolution. Further sequence analyses of CD3E and CD3G from 23 primate species suggested that the Ig domains of CD3E and CD3G underwent the positive Darwinian selection.