Prenatal alcohol exposure and cryptorchidism
Prenatal alcohol exposure and cryptorchidism
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DOI：
10.1111/j.1651-2227.2007.00506.x
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发表时间：
2007-11-01
期刊：
影响因子：
3.8
通讯作者：
Olsen, J.
中科院分区：
文献类型：
--
作者：
Jensen, M. S.;Bonde, J. P.;Olsen, J.
目的：最近发表的一项研究报告说，母亲平均每周摄入五杯或更多的酒精，男孩患隐睾症的风险明显增加。本研究的目的是跟进这一发现，估计产前酒精暴露和持续性隐睾症之间的关联。方法：我们使用前瞻性收集的信息，产前暴露和产科信息出生的5716名男孩，收集1984年至1987年。在16-19年的随访期间，在全国范围内的患者登记，270例隐睾症被诊断和185这些男孩进行orchiopexy.Results：母亲的平均每周饮酒量和持续隐睾症之间没有正相关。酗酒与睾丸固定术的过度风险无显著相关性（调整后的RR = 1.4; 95%CI 0.9-2.1），但与诊断为隐睾而无orchiopexy.Conclusions：母亲的平均每周酒精摄入量与持续隐睾无关，但酗酒可能是一个危险因素。
Aim: A recently published study reported markedly increased risk of cryptorchidism among boys whose mothers had an average gestational alcohol intake of five or more drinks per week. The aim of this study is to follow up on this finding by estimating the association between prenatal alcohol exposure and persistent cryptorchidism.Methods: We used prospectively collected information on prenatal exposures and obstetric information on the birth of 5716 boys, collected from 1984 to 1987. During the 16-19 years of follow-up in a nationwide patient register, 270 cases of cryptorchidism were diagnosed and 185 of these boys underwent orchiopexy.Results: No positive association between the mothers' average weekly alcohol consumption and persistent cryptorchidism was observed. Binge drinking was nonsignificantly associated with an excess risk of orchiopexy (adjusted RR = 1.4; 95% CI 0.9-2.1), but not with having a diagnosis of cryptorchidism without orchiopexy.Conclusions: Mothers' average weekly alcohol intake was not associated with persistent cryptorchidism, but binge drinking may be a risk factor.