Economic Decisions through Circuit Inhibition
Economic Decisions through Circuit Inhibition
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DOI：
10.1016/j.cub.2019.09.027
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发表时间：
2019-11-18
期刊：
影响因子：
9.2
通讯作者：
Padoa-Schioppa, Camillo
中科院分区：
文献类型：
--
作者：
Ballesta, Sebastien;Padoa-Schioppa, Camillo
商品之间的经济选择被认为依赖于眶额皮层（OFC），但决策机制仍然知之甚少。为了阐明这一基本问题，我们记录了猴子在两种果汁中选择的眶额皮层。对时间窗内放电率的分析显示，存在与先前在同时提供下确定的神经元相似的不同神经元组。这一观察结果表明，这两种模式的经济决策是在同一神经回路中形成的。然后，我们研究了决策机制的几个假设。OFC神经元在基于果汁的表示（标记线）中编码良好的身份和价值。与以前的评估相反，我们的数据反对决策依赖于报价值水平上的相互抑制的观点。事实上，我们表明，以前的论点相互抑制混淆的价值范围的差异。相反，决策似乎涉及回路抑制机制，即每个出价值间接抑制了编码相反选择结果的神经元。我们的研究结果调和了以前的各种研究结果，并提供了一个经济选择的神经基础的一般帐户。
Economic choices between goods are thought to rely on the orbitofrontal cortex (OFC), but the decision mechanisms remain poorly understood. To shed light on this fundamental issue, we recorded from the OFC of monkeys choosing between two juices offered sequentially. An analysis of firing rates across time windows revealed the presence of different groups of neurons similar to those previously identified under simultaneous offers. This observation suggested that economic decisions in the two modalities are formed in the same neural circuit. We then examined several hypotheses on the decision mechanisms. OFC neurons encoded good identities and values in a juice-based representation (labeled lines). Contrary to previous assessments, our data argued against the idea that decisions rely on mutual inhibition at the level of offer values. In fact, we showed that previous arguments for mutual inhibition were confounded by differences in value ranges. Instead, decisions seemed to involve mechanisms of circuit inhibition, whereby each offer value indirectly inhibited neurons encoding the opposite choice outcome. Our results reconcile a variety of previous findings and provide a general account for the neuronal underpinnings of economic choices.