Allostasis as a core feature of hierarchical gradients in the human brain
Allostasis as a core feature of hierarchical gradients in the human brain
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DOI：
10.1162/netn_a_00240
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发表时间：
2022-10-01
影响因子：
4.7
通讯作者：
Barrett, Lisa Feldman
中科院分区：
文献类型：
--
作者：
Katsumi, Yuta;Theriault, Jordan E.;Barrett, Lisa Feldman
异稳态指的是大脑对身体需求的预测，并试图在需求出现之前满足这些需求的过程，是更广泛的预测处理框架的一个具体实例。在这篇观点文章中，我们提出，适应是人类大脑的基本功能，由两个层次功能梯度组成的内在结构提供服务。我们的框架，基于跨物种的多模态和多尺度证据的综合，开始勾勒出一个连贯的，神经生物学启发的研究计划，表明预测性能量调节是人类大脑功能的核心，并通过扩展，心理和行为现象，为理论建设和知识积累提供了一个共享的词汇。本文将来自两大科学文献的新证据整合到一个共同的框架中：(a)反映大脑大规模结构结构的功能连接的层次梯度（例如，大脑皮层的层压梯度）；(b)预测处理的方法及其具体实例之一，称为异稳态（即，协调身体内部系统服务的能量资源的预测调节）。这一综合开始勾勒出一个连贯的、受神经生物学启发的框架，表明预测性能量调节是人类大脑功能的核心，进而延伸到心理和行为现象，为理论建设和知识积累提供了一个共享的词汇。
Author Summary Allostasis refers to the process by which the brain anticipates the needs of the body and attempts to meet those needs before they arise, and is one specific instantiation of a broader predictive processing framework. In this perspective article, we propose that allostasis is a basic function of the human brain subserved by an intrinsic architecture composed of two hierarchical functional gradients. Our framework, based on a synthesis of multimodal and multiscale evidence across species, begins to sketch a coherent, neurobiologically inspired research program suggesting that predictive energy regulation is at the core of human brain function, and by extension, psychological and behavioral phenomena, providing a shared vocabulary for theory building and knowledge accumulation.This paper integrates emerging evidence from two broad streams of scientific literature into one common framework: (a) hierarchical gradients of functional connectivity that reflect the brain's large-scale structural architecture (e.g., a lamination gradient in the cerebral cortex); and (b) approaches to predictive processing and one of its specific instantiations called allostasis (i.e., the predictive regulation of energetic resources in the service of coordinating the body's internal systems). This synthesis begins to sketch a coherent, neurobiologically inspired framework suggesting that predictive energy regulation is at the core of human brain function, and by extension, psychological and behavioral phenomena, providing a shared vocabulary for theory building and knowledge accumulation.