Increased risk of traffic accidents in subjects with latent toxoplasmosis: a retrospective case-control study
Increased risk of traffic accidents in subjects with latent toxoplasmosis: a retrospective case-control study
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DOI：
10.1186/1471-2334-2-11
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发表时间：
2002-07-02
影响因子：
3.7
通讯作者：
Smahel, Z
中科院分区：
文献类型：
--
作者：
Flegr, J;Havlicek, J;Smahel, Z
弓形虫感染了全世界30-60%的人类。潜伏性弓形虫病，即终生存在于神经和肌肉组织中的弓形虫囊肿，会导致受感染者的反应时间延长。然而，尚不清楚在实验室中观察到的变化是否会影响受试者在现实生活中的表现。方法采用Mantel-Haenszel年龄分层检验，比较交通事故发生人群（N=146）和同一地区普通人群（N=446）的潜伏性弓形虫病血清阳性率。交通事故相对危险度与抗弓形虫抗体滴度的相关性用Cochran-Armitage检验趋势。结果交通事故组血清阳性率高于一般人群(Chi(MH)(2)=21.45, p
BackgroundThe parasite Toxoplasma gondii infects 30-60% of humans worldwide. Latent toxoplasmosis, i.e., the life-long presence of Toxoplasma cysts in neural ad muscular tissues, leads to prolongation of reaction times in infected subjects. It is not know, however, whether the changes observed in laboratory influence the performance of subjects in real-life situations.MethodsThe seroprevalence of latent toxoplasmosis in subjects involved in traffic accidents (N=146) and in the general population living in the same area (N=446) was compared by a Mantel-Haenszel test for age-stratified data. Correlation between relative risk of traffic accident and a level of anti-Toxoplasma antibody titre was evaluated with the Cochran-Armitage test for trend.ResultsA higher serorevalence was found in the traffic accident set than in the general population (Chi(MH)(2)=21.45, p