P53 overexpression in advanced-stage endometrial adenocarcinoma
P53 overexpression in advanced-stage endometrial adenocarcinoma
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DOI：
10.1016/s0002-9378(96)70036-4
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发表时间：
1996-11-01
影响因子：
9.8
通讯作者：
Berchuck, A
中科院分区：
文献类型：
--
作者：
Kohler, MF;Carney, P;Berchuck, A
结论：子宫内膜癌中p53肿瘤抑制基因的突变和过度表达与晚期和低生存率相关。我们试图确定p53过表达是否是预测晚期子宫内膜腺癌预后不良的独立变量。研究设计：免疫组化评价用于检测179例子宫内膜腺癌石蜡块中p53的表达。p53过度表达见于35%的癌症，并且与更高的分期有关。（p = 0.004）、黑人（p < 0.001）、高年级（p = 0.02）、缺乏激素替代（p = 0.04）和年龄较大（p = 0.05）。除了p53过度表达的频率更高（57%比26%），黑人女性的生存率低于白色女性（p = 0.001），但过度表达与两个种族的生存率都很低。在我们校正激素使用后，多变量分析显示，（p < 0.001），高阶段（p < 0.001），较高级别（p = 0.01），和p53过表达（p = 0.04）预测生存率差。p53在晚期子宫内膜癌中的过度表达是一个与生存率低相关的独立变量，在黑人妇女中更常见，这可能会导致生存中的种族差异。
OBJECTIVES: Mutation and overexpression of the p53 tumor suppressor gene in endometrial cancers are associated with advanced stage and poor survival. We sought to determine whether p53 overexpression is an independent variable predictive of poor prognosis in advanced endometrial adenocarcinomas.STUDY DESIGN: Immunohistochemical evaluation was used to examine p53 expression in paraffin blocks from 179 endometrial adenocarcinomas.RESULTS: p53 overexpression was seen in 35% of cancers and was associated with higher stage (p = 0.004), black race (p < 0.001), higher grade (p = 0.02), lack of hormone replacement (p = 0.04), and older age (p = 0.05). In addition to a higher frequency of p53 overexpression (57% vs 26%), black women had a lower survival rate than white women (p = 0.001), but overexpression was associated with poor survival in both races. After we corrected for hormone use, multivariate analysis revealed that older age (p < 0.001), higher stage (p < 0.001), higher grade (p = 0.01), and p53 overexpression (p = 0.04) were predictive of poor survival.CONCLUSIONS: Overexpression of p53 in advanced-stage endometrial cancers is an independent variable that is associated with poor survival, occurs more frequently in black women, and may contribute to the racial disparity in survival.