Spontaneous foaming during vacuum drying of polyvinylpyrrolidone- and sugar-alcohol mixtures and enhancement of water-dissolution of water insoluble drug
Spontaneous foaming during vacuum drying of polyvinylpyrrolidone- and sugar-alcohol mixtures and enhancement of water-dissolution of water insoluble drug
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DOI：
10.1080/07373937.2020.1822863
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发表时间：
2020-09
影响因子：
3.3
通讯作者：
O. Tramis;Akiho Fujioka;H. Imanaka;N. Ishida;K. Imamura
中科院分区：
文献类型：
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作者：
O. Tramis;Akiho Fujioka;H. Imanaka;N. Ishida;K. Imamura
本文研究了中等真空下PVP 2.5k/乙醇和无定形α-麦芽糖/甲醇溶液的发泡性。我们研究了溶液浓度的影响和容器形状对发泡性的影响。我们发现，自发起泡的容器的形状有很大的影响。溶液的浓度是另一个重要参数，我们的研究结果表明，对于给定的溶液，似乎只有一个狭窄的浓度窗口，使稳定的泡沫形成。当装载模型疏水性药物（布洛芬）时，自发发泡通过溶液的广泛剪切作为额外的混合力来增强药物分子的分散。
Abstract We experimentally investigate the foamability of PVP 2.5k/ethanol and amorphous α-maltose/methanol solution under moderate vacuum. We investigate the influence of the solution concentration and the impact of the container shape on the foamability. We show that spontaneous foaming is strongly influenced by the container’s shape. The concentration of the solution is another important parameter, and our results suggest that, for a given solution, there seems to be only a narrow concentration window that enables the formation of a stable foam. When loaded with a model hydrophobic drug (ibuprofen), the spontaneous foaming enhances the dispersion of the drug molecules, by acting as an additional mixing force through extensive shear of the solution.