The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects
The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects
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DOI：
10.1016/j.ygeno.2004.10.006
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发表时间：
2005-02-01
期刊：
影响因子：
4.4
通讯作者：
Kroismayr, R
中科院分区：
文献类型：
--
作者：
Hochrainer, K;Mayer, H;Kroismayr, R
HERC泛素连接酶家族的特征是存在一个Hect结构域和一个或多个RCC1样结构域。我们报道了两个新成员HERC4和HERC6的鉴定，并根据蛋白大小和结构域结构将该家族细分为一组两个大成员和一组四个小成员。这些小成员共享相似的基因组组织，其中三个映射到染色体区域4q22，表明进化上的凝聚力很强。系统发育分析表明，HERC的祖先出现在线虫中，该家族在整个进化过程中不断扩大。在选定的组织和细胞中，人类小成员的mRNA表达模式被发现是不同的；过度表达的蛋白质显示出类似的胞浆分布。这些数据表明，HERC家族成员在许多方面表现出相似之处，但也有足够的差异表明功能的多样性。(C)2004 Elsevier Inc.保留所有权利。
The HERC family of ubiquitin ligases is characterized by the presence of a HECT domain and one or more RCC1-like domains. We report the identification of two novel members, HERC4 and HERC6, and subdivide the family into one group of two large and one group of four small members according to protein size and domain structure. The small members share a similar genomic organization, three of them mapping to chromosomal region 4q22, indicating strong evolutionary cohesions. Phylogenetic analysis reveals that the HERC ancestor emerged in nematodes and that the family expanded throughout evolution. The mRNA expression pattern of the small human members was found to be diverse in selected tissues and cells; overexpressed proteins display a similar cytosolic distribution. These data indicate that the HERC family members exhibit similarities in many aspects, but also sufficient differences indicating functional diversity. (C) 2004 Elsevier Inc. All rights reserved.