Evolutionary-developmental perspectives on immune system interactions among the pregnant woman, placenta, and fetus, and responses to sexually transmitted infectious agents
Evolutionary-developmental perspectives on immune system interactions among the pregnant woman, placenta, and fetus, and responses to sexually transmitted infectious agents
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DOI：
10.1111/j.1749-6632.2011.06137.x
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Abramowsky, Carlos
中科院分区：
文献类型：
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作者：
Nahmias, Andre J.;Schollin, Jens;Abramowsky, Carlos
一种平衡已经在很长一段时间内在各种免疫系统之间进化了，这些免疫系统在很短的时间内联系在一起：孕妇，胎儿和胎盘。这种平衡受母体对可能经胎盘、产时或通过母乳传播给胎儿/婴儿的传染性病原体的免疫应答的影响，并有助于确定这种免疫应答。这篇综述确定了更新的进化概念和过程，特别是人类胎盘，先天性和适应性免疫系统参与的耐受性，并在应对性传播感染（STI）的代理人，可能是致病的胎儿/婴儿在不同的妊娠期，并在生命的第一年。进化发展（EVO-DEVO）的观点已被应用到复杂的内部和之间，不同的行为者和他们的有益或有害的结果。这种系统发育和个体发育的方法有助于激发几个基本问题，并提出了可能的解释和新的实际干预措施。
A balance has evolved over deep time between the various immune systems of the "triad" that is linked together for a short period: the pregnant woman, the fetus, and the placenta. This balance is affected by, and helps to determine, the immune responses to maternal infectious agents that may be transmitted to the fetus/infant transplacentally, intrapartum, or via breast milk. This review identifies newer evolutionary concepts and processes related particularly to the human placenta, innate and adaptive immune systems involved in tolerance, and in responses to sexually transmitted infectious (STI) agents that may be pathogenic to the fetus/infant at different gestational periods and in the first year of life. An evolutionary developmental (EVO-DEVO) perspective has been applied to the complexities within, and among, the different actors and their beneficial or deleterious outcomes. Such a phylogenetic and ontogenic approach has helped to stimulate several basic questions and suggested possible explanations and novel practical interventions.