Immunoglobulin G subclass deficiency: fact or fancy?
Immunoglobulin G subclass deficiency: fact or fancy?
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DOI：
10.1007/s11882-002-0067-1
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发表时间：
2002-09-01
影响因子：
5.5
通讯作者：
Buckley, Rebecca H
中科院分区：
文献类型：
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作者：
Buckley, Rebecca H
在过去的四十年中，据报道许多患者尽管血清总IgG浓度正常，但存在一种或多种IgG亚类缺乏。然而，除了那些IgG2浓度极低或缺失且无法产生针对多糖抗原的抗体的患者外，很难了解众多所报道的IgG亚类缺乏的真正生物学意义。由于重链基因缺失而完全缺乏IgG1、IgG2、IgG4或IgA1但能正常产生抗体的完全无症状个体已有相关描述。此外，对许多IgG2水平较低但免疫接种时对多糖抗原反应正常的健康儿童也有类似描述。从这些观察结果可以得出结论，IgG亚类检测在免疫功能的一般评估中不是很有帮助。此类检测无法提供有关患者产生针对蛋白质、多糖或病毒抗原的特异性抗体能力的信息。
Over the past four decades, many patients have been reported to have deficiencies of one or more subclasses of immunoglobulin G (IgG), despite normal total IgG serum concentrations. However, except for those with extremely low or absent IgG2 concentrations and an inability to produce antibodies to polysaccharide antigens, it is difficult to know the true biologic significance of the many reported IgG subclass deficiencies. Completely asymptomatic individuals who totally lack IgG1, IgG2, IgG4, or IgA1 because of heavy-chain gene deletions have been described as producing antibodies normally. In addition, numerous healthy children who have low levels of IgG2 but normal responses to polysaccharide antigens when immunized have been similarly described. From these observations, it can be concluded that IgG subclass measurement is not very helpful in the general assessment of immune function. Such assays provide no information about the patient's capacity to produce specific antibodies to protein, polysaccharide, or viral antigens.