EFFECT OF INDUCED SYNOVIAL INFLAMMATION ON PHARMACOKINETICS AND SYNOVIAL CONCENTRATION OF SODIUM AMPICILLIN AND KANAMYCIN SULFATE AFTER SYSTEMIC ADMINISTRATION IN PONIES
EFFECT OF INDUCED SYNOVIAL INFLAMMATION ON PHARMACOKINETICS AND SYNOVIAL CONCENTRATION OF SODIUM AMPICILLIN AND KANAMYCIN SULFATE AFTER SYSTEMIC ADMINISTRATION IN PONIES
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DOI：
10.1111/j.1365-2885.1988.tb00121.x
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发表时间：
1988-03-01
影响因子：
1.3
通讯作者：
WENSING, T
中科院分区：
文献类型：
--
作者：
FIRTH, EC;KLEIN, WR;WENSING, T
将单剂量的氨苄西林钠（10 mg/kg）和硫酸卡那霉素（5 mg/kg）分别肌内注射（i.m.），然后一起给予五匹小母马。绘制血浆抗生素浓度-时间曲线。单独给予的抗生素的药代动力学参数不会因同时给药而改变。随后，五匹小母马中的四匹被授予“IM”称号。左腕骨间关节注射脂多糖引起急性滑膜炎和发热后4小时，卡那霉素/氨苄西林联合用药。构建发炎关节和正常关节的血浆浓度-时间曲线和滑液浓度-时间曲线。脂多糖实验中氨苄青霉素的Cmax显着高于其他实验。与未发炎的关节相比，抗生素更快地进入发炎关节的滑液并达到更高的浓度。注射后约2.5小时，发炎滑液中氨苄西林浓度超过5μg/ml，硫酸卡那霉素浓度超过2μg/ml达7小时。
Single doses of sodium ampicillin (10 mg/kg) and kanamycin sulfate (5 mg/kg) were administered intramuscularly (i.m.) separately, and then together, to five pony mares. The plasma antibiotic concentration-time curves were constructed. The pharmacokinetic parameters of the antibiotics given separately were not altered by concurrent administration. Four of the five pony mares were then given the i.m. kanamycin/ampicillin combination 4 h after acute synovitis and fever had been induced by injection of lipopolysaccharide into the left intercarpal joint. The plasma concentration-time curves and the synovial concentration-time curves of inflamed and normal joints were constructed. The Cmax of ampicillin in the lipopolysaccharide experiment was significantly higher than in the other experiments. The antibiotics entered the synovial fluid of the inflamed joints more quickly and attained higher concentrations than in the uninflamed joints. The ampicillin concentration exceeded 5 .mu.g/ml in inflamed synovial fluid for some 2.5 h after injection, and kanamycin sulfate concentration exceeded 2 .mu.g/ml for 7 h.