Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis
Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis
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DOI：
10.1016/j.atherosclerosis.2007.01.004
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发表时间：
2008-02-01
期刊：
影响因子：
5.3
通讯作者：
Stein, C. Michael
中科院分区：
文献类型：
--
作者：
Chung, Cecilia P.;Oeser, Annette;Stein, C. Michael
类风湿性关节炎（RA）患者动脉粥样硬化加速。代谢综合征是一组心血管风险因素，可识别心血管风险。我们检验了RA患者代谢综合征患病率较高的假设，特别是WHO定义的需要胰岛素抵抗的综合征，并且这与冠状动脉粥样硬化有关。使用修订的WHO和NCEP III标准，在154例RA患者（88例早期RA和66例长期RA）和85例对照组中确定代谢综合征的患病率。冠状动脉粥样硬化通过电子束计算机断层扫描检测。WHO定义的代谢综合征存在于42%的长期RA患者、31%的早期RA患者和11%的对照组（P < 0.001）; NCEP定义的代谢综合征存在于42%的长期RA患者、30%的早期RA患者和22%的对照组（P=0.03）。WHO定义的代谢综合征患者具有较高的冠状动脉钙化评分的风险增加，与年龄和性别无关（OR=2.02，95%CI：1.03 - 3.97，P=0.04）。总之，类风湿关节炎患者的代谢综合征患病率高于对照组。炎症相关代谢综合征是RA患者冠状动脉粥样硬化增加的一种机制。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Patients with rheumatoid arthritis (RA) have accelerated atherosclerosis. The metabolic syndrome, a cluster of cardiovascular risk factors, identifies cardiovascular risk. We tested the hypotheses that patients with RA have a higher prevalence of the metabolic syndrome, particularly the WHO-defined syndrome that requires insulin resistance, and that this is associated with coronary atherosclerosis. The prevalence of the metabolic syndrome was determined using the modified WHO and NCEP III criteria in 154 patients with RA (88 with early RA and 66 with long-standing RA) and 85 control subjects. Coronary-artery atherosclerosis was detected by electron beam computed tomography. The WHO-defined metabolic syndrome was present in 42% of patients with long-standing RA, 31% with early RA and 11% of controls (P < 0.001); the NCEP-defined metabolic syndrome was present in 42% of patients with long-standing RA, 30% with early RA and 22% of controls (P=0.03). Patients with the WHO-defined metabolic syndrome had an increased risk of having higher coronary-artery calcification scores, independent of age and sex (OR=2.02, 95% CI: 1.03 - 3.97, P=0.04). In conclusion, patients with RA have a higher prevalence of the metabolic syndrome than control subjects. Inflammation-associated metabolic syndrome is a mechanism that may contribute to increased coronary-artery atherosclerosis in RA. (c) 2007 Elsevier Ireland Ltd. All rights reserved.