STRUCTURE AND COMPOSITION OF MICROCALCIFICATIONS IN BENIGN AND MALIGNANT LESIONS OF THE BREAST - STUDY BY LIGHT-MICROSCOPY, TRANSMISSION AND SCANNING ELECTRON-MICROSCOPY, MICROPROBE ANALYSIS, AND X-RAY-DIFFRACTION
STRUCTURE AND COMPOSITION OF MICROCALCIFICATIONS IN BENIGN AND MALIGNANT LESIONS OF THE BREAST - STUDY BY LIGHT-MICROSCOPY, TRANSMISSION AND SCANNING ELECTRON-MICROSCOPY, MICROPROBE ANALYSIS, AND X-RAY-DIFFRACTION
复制标题
DOI：
10.1016/s0046-8177(84)80150-1
复制
发表时间：
1984-01-01
期刊：
影响因子：
3.3
通讯作者：
FEROLDI, J
中科院分区：
文献类型：
--
作者：
FRAPPART, L;BOUDEULLE, M;FEROLDI, J
从25例肿瘤切除或系统化乳腺摘除患者的新鲜标本中提取先前通过放射学定位的微钙化。区分了两种主要类型的微钙化。扫描电子显微镜下，I型微钙化呈琥珀色，大体呈结晶状，微探针分析仅见1个钙峰；X-射线衍射仪显示钙化受累。II型微钙化在偏振光下呈白色，无双折射，在显微探针分析中呈卵圆形或梭形，有两个峰，一个是钙，另一个是P，在透射电子显微镜下这些微钙化是由磷酸钙组成，最具特征的形式是羟基磷灰石，呈针状排列。8例乳腺良性病变中4例可见I型微钙化，3例小叶原位癌中2例可见微钙化，导管内腺癌和浸润性癌均未见微钙化。所有浸润性癌和导管内腺癌均存在II型微钙化，良性病变中也有微钙化(4/8)，1例原位小叶癌还伴有I型微钙化。因此，没有良性或恶性的微钙化；然而，楔形卫星的存在是一个强烈的迹象，表明病变是良性的，最多是原位小叶癌。
Microcalcifications previously located by radiography were extracted from 25 fresh specimens obtained from patients who had undergone tumorectomy or systematized mammary exeresis. Two principal types of microcalcifications were distinguished. Type I microcalcifications were amber in color and generally crystalline on scanning electron microscopy, with only 1 calcium peak on microprobe analysis; X-ray diffraction revealed that weddellite was involved. Type II microcalcifications were whitish, nonbirefringent under polarized light, and generally ovoid or fusiform, with 2 peaks, 1 calcium and the other P, on microprobe analysis; these microcalcifications were composed of calcium phosphate, the most characteristic form of which is hydroxyapatite, in the form of needles arranged in rosettes on transmission electron microscopy. Type I microcalcifications were observed in 4 of 8 benign breast lesions, in 2 of 3 in situ lobular carcinomas, and in no intraductal adenocarcinomas or infiltrating carcinomas. Type II microcalcifiations were present in all infiltrating carcinomas and intraductal adenocarcinomas; they were also found in benign lesions (four of eight) and even associated with type I microcalcifications in one in situ lobular carcinoma. There are, therefore, no benign or malignant microcalcifications; however, the presence of weddellite is a strong indication that a lesion is benign or, at most, an in situ lobular carcinoma.