Studies of the tumorigenic potential of 4-substituted phenylhydrazines by the subcutaneous route.
Studies of the tumorigenic potential of 4-substituted phenylhydrazines by the subcutaneous route.
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DOI：
10.1080/15287398109530045
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发表时间：
1981-07
期刊：
影响因子：
--
通讯作者：
Bela Toth;Donald Nagel
中科院分区：
文献类型：
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作者：
Bela Toth;Donald Nagel
4-将甲基苯肼盐酸盐（4-MPH）以每克体重140微克的剂量每周皮下注射26次给药于随机繁殖的Swiss小鼠，并将N ′-乙酰基-4-（羟甲基）苯肼（AMPH）以500微克/克的剂量每周皮下注射26次给药于随机繁殖的Swiss小鼠。作为溶剂对照，生理盐水也以0.01ml/g的剂量每周皮下注射26次。4-MPH给药诱导了雄性动物中纤维肉瘤的显著发生率（24%）。在4-MPH给药雌性和一些AMPH给药雄性小鼠中，观察到一些软组织肿瘤;然而，其外观与给药无关。4-MPH是在特殊的实验条件下由4-羟甲基苯肼形成的，4-羟甲基苯肼是栽培蘑菇双孢蘑菇的成分--琼脂碱的体外分解产物。本文详细讨论了这些发现的意义。
4-Methylphenylhydrazine hydrochloride (4-MPH) was administered to randomly bred Swiss mice as 26 weekly sc injections of 140 microgram per gram of body weight and N'-acetyl-4-(hydroxymethyl)phenylhydrazine (AMPH) as 26 weekly sc injections of 500 microgram/g. As a solvent control, physiological saline was also given as 26 weekly sc injections of 0.01 ml/g. The 4-MPH treatment induced a significant incidence (24%) of fibrosarcomas in males. In the 4-MPH-treated females and some AMPH-treated male mice, a few soft-tissue tumors were observed; however, their appearance could not be related to treatment. 4-MPH is formed under special experimental conditions from 4-hydroxymethylphenyl-hydrazine, which is an in vitro breakdown product of agaritine, an ingredient of the cultivated mushroom Agaricus bisporus. The implications of the findings are discussed.