Experimental Cerebral Chromoblastomycosis.
Experimental Cerebral Chromoblastomycosis.
复制标题
实验性脑染色芽生菌病。
DOI：
10.1093/infdis/111.1.1
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发表时间：
1962
期刊：
影响因子：
--
通讯作者：
L. Friedman
中科院分区：
文献类型：
--
作者：
Charles E. Felger;L. Friedman
A brief history of cerebral chromoblastomycosis is discussed along with that of its dermal counterpart, cutaneous chromoblastomycosis. This study investigates the possible role of both saprophytic and pathogenic "black molds" as causative agents of cerebral chromoblastomycosis. Viable spores of the following species were injected either intravenously or intracerebrally into both normal and cortisone-antibiotic-treated mice: Cladosporium trichoides (a causative agent of cerebral chromoblastomycosis); Hormodendrum pedrosoi, Hormodendrum compactum, and Phialophora verrucosa (etiologic agents of cutaneous chromoblastomycosis); and 3 Hormodendrum species isolated from the air. All of the agents of human chromoblastomycosis (cerebral or cutaneous) produced fatal cerebral infections in varying numbers of mice under 1 or more of the experimental conditions employed. The route of inoculation or pretreatment with cortisone and antibiotics were important determining factors. Although a difference was observed in the virulence of various agents, the morphology of the hyphae in the lesions was indistinguishable. There were no deaths in the groups receiving the 3 saprophytic Hormodendrum species. The ability of cortisone to suppress the inflammatory responses of tissue is well confirmed in this study, particularly by the greatly diminished macrophage response observed in mice pre-treated with this glucocorticoid.
