Risk of Mental Illness in Offspring of Parents With Schizophrenia, Bipolar Disorder, and Major Depressive Disorder: A Meta-Analysis of Family High-Risk Studies
Risk of Mental Illness in Offspring of Parents With Schizophrenia, Bipolar Disorder, and Major Depressive Disorder: A Meta-Analysis of Family High-Risk Studies
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DOI：
10.1093/schbul/sbt114
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发表时间：
2014-01-01
影响因子：
6.6
通讯作者：
Uher, Rudolf
中科院分区：
文献类型：
--
作者：
Rasic, Daniel;Hajek, Tomas;Uher, Rudolf
目的：父母患有严重精神疾病（重度精神障碍、精神分裂症、双相情感障碍、重度抑郁症）的后代患精神疾病的风险增加。我们的目的是量化后代精神障碍的风险，并确定增加的风险是否超出了父母的障碍。方法：荟萃分析截至2012年12月发表的家庭高危研究中患有精神分裂症、双相情感障碍或抑郁症的父母的后代精神障碍的绝对和相对发生率。结果：我们纳入了33项研究，共3863名重度精神障碍父母的后代和3158名对照后代。父母患有重度精神障碍的后代在成年（20岁至20岁）时患重度精神障碍的概率为32% （95% CI: 24%-42%）。这一风险是对照组子代的两倍多(风险比[RR] 2.52; 95% CI 2.08-3.06， P
Objective: Offspring of parents with severe mental illness (SMI; schizophrenia, bipolar disorder, major depressive disorder) are at an increased risk of developing mental illness. We aimed to quantify the risk of mental disorders in offspring and determine whether increased risk extends beyond the disorder present in the parent. Method: Meta-analyses of absolute and relative rates of mental disorders in offspring of parents with schizophrenia, bipolar disorder, or depression in family high-risk studies published by December 2012. Results: We included 33 studies with 3863 offspring of parents with SMI and 3158 control offspring. Offspring of parents with SMI had a 32% probability of developing SMI (95% CI: 24%-42%) by adulthood (age > 20). This risk was more than twice that of control offspring (risk ratio [RR] 2.52; 95% CI 2.08-3.06, P