Gains of chromosomes 7 and 17 in tubulocystic carcinoma of kidney: two cases with fluorescence in situ hybridisation analysis
Gains of chromosomes 7 and 17 in tubulocystic carcinoma of kidney: two cases with fluorescence in situ hybridisation analysis
复制标题
肾管囊性癌7、17号染色体的获得：荧光原位杂交分析二例
DOI：
10.1136/jclinpath-2014-202363
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发表时间：
2014-11-01
影响因子：
3.4
通讯作者：
Zhou, Qiao
中科院分区：
文献类型：
--
作者：
Chen, Ni;Nie, Ling;Zhou, Qiao
肾小管囊性癌（TCC）是一种非常罕见的肾脏肿瘤，具有独特的肉眼和显微镜特征，也被认为是低度集合管癌。最近的研究倾向于将TCC与集合管癌区分开来，并且描述了一些TCC与其他肾细胞肿瘤亚型同时并存的病例。我们在这里报告两个新的情况下，纯（例1）或混合（例2）TCC与荧光原位杂交（FISH）分析，这表明增益的7号和17号染色体在纯TCC的情况下，以及在TCC和乳头状肾细胞癌（PRCC）的成分的情况下2。这些数据可能进一步支持TCC与PRCC更密切相关的观点。
Tubulocystic carcinoma (TCC) is a very rare renal tumour with unique gross and microscopic features, alternatively considered as low-grade collecting duct carcinoma. Recent studies favoured distinction of TCC from collecting duct carcinoma, and some cases of TCC synchronously coexisting with other renal cell tumour subtypes were described. We report here two new cases of pure (case 1) or mixed (case 2) TCC with fluorescence in situ hybridisation (FISH) analysis, which showed gains of chromosomes 7 and 17 in the pure TCC of case 1, as well as in the TCC and the papillary renal cell carcinoma (PRCC) components in case 2. These data may further support the notion that TCC is more closely related to PRCC.