Photodynamic Therapy Is Effective Against Candida auris Biofilms.
Photodynamic Therapy Is Effective Against Candida auris Biofilms.
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DOI：
10.3389/fcimb.2021.713092
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发表时间：
2021
影响因子：
5.7
通讯作者：
Nobile CJ
中科院分区：
文献类型：
--
作者：
Bapat PS;Nobile CJ
真菌感染在世界范围内的流行率正在上升。可用的抗真菌药物种类的缺乏，加上真菌中多药耐药性的增加，导致了真菌感染治疗的新的临床挑战。耳念珠菌是近年来发现的一种具有多重耐药性的人类真菌病原体，已成为全球性的公共卫生威胁。C.耳念珠菌临床分离株通常对一种或多种抗真菌药物类别具有抗性，因此，对于开发有效对抗念珠菌的新治疗策略存在高度未满足的医学需求。耳。此外，C. auris具有几种毒力特征，包括形成生物膜的能力，进一步促进其耐药性，并使C.耳感染。在这里，我们评估了单独的红色、绿色和蓝色可见光以及与光敏化合物组合的红色、绿色和蓝色可见光对C.耳生物膜结果表明：（1）蓝光对C.（2）红光抑制和破坏了C. auris的生物膜，而光敏化合物的加入提高了其生物膜电位。（3）绿色光抑制C. auris生物膜，但仅与光敏化合物联合作用。光敏感化合物对破坏耳念珠菌生物膜没有影响。耳生物膜综上所述，我们的研究结果表明，光动力疗法可能是一种有效的非药物治疗策略，对多药耐药的C。耳生物膜感染。
Fungal infections are increasing in prevalence worldwide. The paucity of available antifungal drug classes, combined with the increased occurrence of multidrug resistance in fungi, has led to new clinical challenges in the treatment of fungal infections. Candida auris is a recently emerged multidrug resistant human fungal pathogen that has become a worldwide public health threat. C. auris clinical isolates are often resistant to one or more antifungal drug classes, and thus, there is a high unmet medical need for the development of new therapeutic strategies effective against C. auris. Additionally, C. auris possesses several virulence traits, including the ability to form biofilms, further contributing to its drug resistance, and complicating the treatment of C. auris infections. Here we assessed red, green, and blue visible lights alone and in combination with photosensitizing compounds for their efficacies against C. auris biofilms. We found that (1) blue light inhibited and disrupted C. auris biofilms on its own and that the addition of photosensitizing compounds improved its antibiofilm potential; (2) red light inhibited and disrupted C. auris biofilms, but only in combination with photosensitizing compounds; and (3) green light inhibited C. auris biofilms in combination with photosensitizing compounds, but had no effects on disrupting C. auris biofilms. Taken together, our findings suggest that photodynamic therapy could be an effective non-drug therapeutic strategy against multidrug resistant C. auris biofilm infections.