Transient haemodynamic events in neurologically compromised infants: A simultaneous EEG and diffuse optical imaging study
Transient haemodynamic events in neurologically compromised infants: A simultaneous EEG and diffuse optical imaging study
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DOI：
10.1016/j.neuroimage.2011.01.022
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发表时间：
2011-04-15
期刊：
影响因子：
5.7
通讯作者：
Austin, T.
中科院分区：
文献类型：
--
作者：
Cooper, R. J.;Hebden, Jeremy C.;Austin, T.
我们描述了一系列新的同步脑电图和弥散光学成像研究的新生儿。这些实验提供了大量的、短暂的血液动力学事件的证据，这些事件在几个神经损伤的婴儿体内和之间反复和一致地发生，所有这些婴儿都被诊断为癫痫发作。一个简单但独立的过程中，拒绝伪影和扩散光学成像数据内的事件进行了描述，这个过程适用于从4个神经损伤的新生儿和19个健康的，年龄匹配的控制数据。该方法导致在神经受损婴儿组的四分之三中一致地鉴定事件，其主要是氧合血红蛋白浓度的缓慢（>30 s）和显著增加，随后是在缓慢返回基线之前的快速和显著降低。在我们的任何对照数据集中均未发现可比事件。我们的研究结果的重要性和生理意义进行了讨论，以及组合的EEG和漫射光学成像方法对新生儿脑损伤研究和监测的适用性。(C)2011 Elsevier Inc. All rights reserved.
We describe a series of novel simultaneous EEG and diffuse optical imaging studies of newborn infants. These experiments provide evidence of large, transient haemodynamic events which occur repeatedly and consistently within and across several infants with neurological damage, all of whom were diagnosed with seizures. A simple but independent process of rejecting artifacts and identifying events within diffuse optical imaging data is described, and this process is applied to data from 4 neurologically damaged neonates and from 19 healthy, age-matched controls. This method results in the consistent identification of events in three out of four of the neurologically damaged infant group which are dominated by a slow (>30 s) and significant increase in oxyhaemoglobin concentration, followed by a rapid and significant decrease before a slow return to baseline. No comparable events are found in any of our control data sets. The importance and physiological implications of our findings are discussed, as is the suitability of a combined EEG and diffuse optical imaging approach to the study and monitoring of neonatal brain injury. (C) 2011 Elsevier Inc. All rights reserved.