Gender Differences in Concerns About Participating in Cancer Research During the COVID-19 Pandemic.
Gender Differences in Concerns About Participating in Cancer Research During the COVID-19 Pandemic.
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DOI：
10.1177/1073274821989315
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Van Hemelrijck M
中科院分区：
文献类型：
--
作者：
Fox L;Wylie H;Cahill F;Haire A;Green S;Kibaru J;Hartley C;Sullivan R;Van Hemelrijck M
正在进行的SARS-CoV-2大流行对癌症研究产生了重大影响，包括癌症临床试验参与者人数的大幅减少。现有的研究表明，癌症临床试验的累积率急剧下降可能会对女性产生不成比例的影响。我们试图确定在收集的数据集中是否存在性别差异，以检查参与者对在大流行期间参加癌症研究的担忧。在2020年6月5日至19日期间，我们通过社交媒体发布了一份完全匿名的调查。我们联系了85个英国癌症患者组织/慈善机构，并要求他们在他们的平台上分享我们的调查问卷，其中26个有义务。18岁的癌症诊断患者有资格参加，并询问他们的临床和人口统计学特征，考虑到COVID-19大流行对研究参与的担忧，使用广泛性焦虑症-7（GAD-7）量表测量的焦虑水平等问题。使用单变量和多变量分析比较了男性和女性的焦虑水平和对参与的担忧。93名个体，包括各种癌症类型的n = 37名女性和n = 56名男性，提供了调查回答。独立的t检验显示，女性报告的焦虑评分以及对COVID-19期间参与癌症研究的担忧高于男性。线性回归分析表明，焦虑分数预测的妇女，而不是男性参与研究的关注（pinteraction = 0.002）。癌症患者对在COVID-19大流行期间参与研究的担忧程度从轻度到严重不等。此外，一般性焦虑和对研究参与的关注之间的关系可能是更相关的，更明显的女性比男性。未来的工作应该研究为什么女性在COVID-19大流行期间不太可能参加癌症试验。
The ongoing SARS-CoV-2 pandemic is having major effects on cancer research, including major reductions in participant accrual to cancer clinical trials. Existing research has indicated that these steep drops in accrual rates to cancer clinical trials may be disproportionately affecting women. We sought to determine if there were gender differences in a dataset collected to examine participants’ concerns about taking part in cancer research during the pandemic. Between 5-19 June 2020, we distributed a fully anonymized survey via social media. We contacted 85 UK cancer patient organizations/charities and asked them to share our questionnaire on their platforms, of which 26 obliged. Patients aged 18 with a cancer diagnosis were eligible to participate and asked about their clinical and demographic characteristics, concerns about research participation given the COVID-19 pandemic, anxiety levels measured using the Generalized Anxiety Disorder-7 (GAD-7) scale, amongst other questions. Anxiety levels and concerns about participating were compared between men and women using univariate and multivariate analyses. 93 individuals, comprising n = 37 women and n = 56 men of various cancer types, provided survey responses. Independent t-tests showed that women reported higher anxiety scores, and concerns about participating in cancer research during COVID-19, than men. Linear regression analyses showed that anxiety scores predicted concerns about research participation in women but not men (pinteraction = 0.002). Cancer patients have concerns about participating in research during the COVID-19 pandemic that range from mild to serious. Furthermore, the relationship between general anxiety and concerns about research participation may be both more relevant and more pronounced in women than in men. Future work should examine the reasons why women are less likely to enrol in cancer trials during the COVID-19 pandemic.
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