Iterative reconstruction: an improvement of technetium-99m MIBI SPET for the detection of parathyroid adenomas?
Iterative reconstruction: an improvement of technetium-99m MIBI SPET for the detection of parathyroid adenomas?
复制标题
迭代重建：锝-99m MIBI SPET 用于甲状旁腺腺瘤检测的改进？
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
H. Schicha
中科院分区：
文献类型：
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作者：
D. Moka;W. Eschner;E. Voth;M. Dietlein;A. Larena;H. Schicha
摘要：本研究的目的是评估锝-99 m甲氧基异丁基异腈（MIBI）单光子发射断层扫描（SPET）和迭代重建算法对甲状旁腺腺瘤（PTA）术前定位的价值。对72例已知原发性甲状旁腺功能亢进患者（男26例，女46例，平均年龄58±16岁）进行术前检查。首先，进行甲状腺检查，以检测可能的MIBI蓄积性甲状腺病变。在静脉注射740 MBq 99 mTc-MIBI后15和120 min，使用三头伽马照相机（Picker Prism 3000）采集平面扫描和120 min断层图像。此外，还对早期平面图像进行了99 mTc-MIBI/99 mTc-pertechnetate减影成像。使用迭代重建（乘法迭代SPET重建：MISR）以及标准算法（FBP：应用3-D低通后置滤波器的滤波反投影）评价SPET数据。切除的PTA的重量范围为110 mg至5 g。使用平面MIBI扫描，在81%的病例中可以正确定位PTA侧（重量小于500 mg的PTA为58%）。使用SPET和FBP的灵敏度增加到94%，而使用MISR的灵敏度进一步上升到97%。体重小于500 mg的PTA患者对MISR的敏感性为88%，对FBP的敏感性为81%。此外，使用MISR的图像质量有明显改善。未观察到正常甲状旁腺。这项研究表明，与平面CT相比，99 mTc-MIBI SPET是一个更敏感和更具体的工具，地形定位的PTA，特别是那些小的。当使用迭代重建代替FBP时，灵敏度和图像质量有进一步的改善。
Abstract.The purpose of this study was to assess the value of technetium-99m methoxyisobutylisonitrile (MIBI) single-photon emission tomography (SPET) and an iterative reconstruction algorithm for the preoperative localisation of parathyroid adenomas (PTAs). Seventy-two patients (26 male, 46 female, mean age 58±16 years) with known primary hyperparathyroidism were examined preoperatively. First, a thyroid examination was performed to detect possible MIBI-accumulating thyroid lesions. Planar scans were then acquired 15 and 120 min and tomographic images 120 min after intravenous injection of 740 MBq 99mTc-MIBI, using a triple-head gamma camera (Picker Prism 3000). Additionally, 99mTc-MIBI/ 99mTc-pertechnetate subtraction scintigraphy of the early planar images was performed. The SPET data were evaluated using an iterative reconstruction (multiplicative iterative SPET reconstruction: MISR) as well as a standard algorithm (FBP: filtered back-projection with application of a 3-D low-pass postfilter). The weight of the resected PTAs ranged from 110 mg to 5 g. Using planar MIBI scans, correct localisation of the side of the PTA was possible in 81% of cases (58% for PTAs weighing less than 500 mg). Sensitivity increased to 94% using SPET and FBP, while with MISR it rose further, to 97%. Patients with PTAs weighing less than 500 mg showed a sensitivity of 88% with MISR and 81% with FBP. Furthermore, there was a clear improvement in image quality using MISR. None of the normal parathyroid glands were visualised. This study indicates that, in comparison with planar scintigraphy, 99mTc-MIBI SPET is a more sensitive and specific tool for topographical localisation of PTAs, especially those that are small. There is a further improvement in sensitivity and image quality when iterative reconstruction is used instead of FBP.
甲状旁腺肿瘤的放射性核素、计算机断层扫描、超声检查和磁共振定位的前瞻性比较。
影响因子：
3.8
作者：
Krubsack,AJ;Wilson,SD;Lawson,TL;Kneeland,JB;Thorsen,MK;Collier,BD;Hellman,RS;Isitman,AT
通讯作者：
Isitman,AT