ELECTRON-MICROSCOPIC ANALYSIS OF THE ROD PATHWAY OF THE RAT RETINA
ELECTRON-MICROSCOPIC ANALYSIS OF THE ROD PATHWAY OF THE RAT RETINA
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DOI：
10.1002/cne.903320404
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发表时间：
1993-06-22
影响因子：
2.5
通讯作者：
WASSLE, H
中科院分区：
文献类型：
--
作者：
CHUN, MH;HAN, SH;WASSLE, H
用两种免疫细胞化学标记物标记大鼠视网膜杆状通路。Rod双极细胞用蛋白激酶C抗体染色，AII-amacrine细胞用小白蛋白抗体染色。研究了内丛状层杆状双极的突触回路。杆状双极细胞在IPL中产生大约15个带状突触（二联）。二体的两个突触后成员都是无毛细胞；其中一个通常是一个ai -amacrine细胞的过程，另一个经常提供一个互惠突触。杆状双极细胞没有直接输出到神经节细胞。AII-amacrine细胞与眼下a区的锥状双极细胞和神经节细胞形成化学输出突触。它们与层下b的锥形双极细胞和其他aii -无突细胞形成间隙连接。大鼠视网膜的视杆通路实际上与猫和兔子的视网膜完全相同。这种电路很可能是哺乳动物视网膜组织的一个普遍特征。
Two immunocytochemical markers were used to label the rod pathway of the rat retina. Rod bipolar cells were stained with antibodies against protein kinase C and AII-amacrine cells with antibodies against parvalbumin. The synaptic circuitry of rod bipolars in the inner plexiform layer (IPL) was studied. Rod bipolar cells make approximately 15 ribbon synapses (dyads) in the IPL. Both postsynaptic members of the dyads are amacrine cells; one is usually the process of an AII-amacrine cell and the other one frequently provides a reciprocal synapse. No direct output from rod bipolar cells into ganglion cells was found. AII-amacrine cells make chemical output synapses with cone bipolar cells and ganglion cells in sublamina a of the IPL. They make gap junctions with cone bipolar cells and other AII-amacrine cells in sublamina b of the IPL. The rod pathway of the rat retina is practically identical to that of the cat and of the rabbit retina. It is very likely that this circuitry is a general feature of mammalian retinal organization.