Electrochemical synthesis of euglobal-G1, -G2, -G3, -G4, -T1 and -IIc
Electrochemical synthesis of euglobal-G1, -G2, -G3, -G4, -T1 and -IIc
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DOI：
10.1039/a802306i
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发表时间：
1998-09-07
期刊：
影响因子：
--
通讯作者：
Tada, M
中科院分区：
文献类型：
--
作者：
Chiba, K;Arakawa, T;Tada, M
用电化学方法合成了六种天然优球蛋白。在关键步骤中，以2，3-二氯-5，6-二氰基对苯二酚（DDQH（2））为氧化还原介质，原位生成的醌类化合物与萜烯类化合物在PTFE纤维涂层电极表面进行环加成反应，生成天然产物。
Six natural euglobals were synthesized by electrochemical methods. In a key step, cycloaddition between in situ generated quinomethanes and terpenes was performed on the surface of PTFE-fibre coated electrode to give natural products using 2,3-dichloro-5,6-dicyano-p-hydroquinone (DDQH(2)) as a redox mediator, In this reaction system, biomimetic generation and cycloaddition of the unstable quinomethanes were efficiently completed by the selective oxidation of cresol derivatives.