SubtiWiki 2.0--an integrated database for the model organism Bacillus subtilis.
SubtiWiki 2.0--an integrated database for the model organism Bacillus subtilis.
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DOI：
10.1093/nar/gkv1006
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发表时间：
2016-01-04
影响因子：
14.9
通讯作者：
Stülke J
中科院分区：
文献类型：
--
作者：
Michna RH;Zhu B;Mäder U;Stülke J
为了了解活细胞，我们需要了解它们的每个部分以及这些部分之间的相互作用。为了获得快速和全面的访问这些信息，需要注释数据库。在这里，我们提出了SubtiWiki 2.0，模式细菌枯草芽孢杆菌的集成数据库（http：//subtiwiki.uni-goettingen.de/）。SubtiWiki提供了基于文本的访问关于B的基因和蛋白质的公开信息。枯草杆菌以及代谢和调节途径的介绍。此外，手动策划的蛋白质-蛋白质相互作用图链接到蛋白质页面。最后，显示了在104种不同条件下的基因表达以及细胞质蛋白的绝对蛋白定量的表达数据。为了方便移动的使用SubtiWiki，我们现在通过适用于iOS和Android设备的应用程序对其进行了扩展。重要的是，该应用程序允许将私人笔记和图片链接到基因/蛋白质页面。今天，SubtiWiki已经成为一个单一资源中最完整的生物知识集合之一。
To understand living cells, we need knowledge of each of their parts as well as about the interactions of these parts. To gain rapid and comprehensive access to this information, annotation databases are required. Here, we present SubtiWiki 2.0, the integrated database for the model bacterium Bacillus subtilis (http://subtiwiki.uni-goettingen.de/). SubtiWiki provides text-based access to published information about the genes and proteins of B. subtilis as well as presentations of metabolic and regulatory pathways. Moreover, manually curated protein-protein interactions diagrams are linked to the protein pages. Finally, expression data are shown with respect to gene expression under 104 different conditions as well as absolute protein quantification for cytoplasmic proteins. To facilitate the mobile use of SubtiWiki, we have now expanded it by Apps that are available for iOS and Android devices. Importantly, the App allows to link private notes and pictures to the gene/protein pages. Today, SubtiWiki has become one of the most complete collections of knowledge on a living organism in one single resource.