The biocompatibility (cell culture and histologic study) of hydroxy-apatite-coated implants created by ion beam dynamic mixing.
The biocompatibility (cell culture and histologic study) of hydroxy-apatite-coated implants created by ion beam dynamic mixing.
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通过离子束动态混合创建的羟基磷灰石涂层植入物的生物相容性（细胞培养和组织学研究）。
DOI：
10.1034/j.1600-0501.1996.070202.x
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发表时间：
1996
影响因子：
4.3
通讯作者：
T. Dérand
中科院分区：
文献类型：
--
作者：
M. Yoshinari;B. Klinge;T. Dérand
采用离子束动态混合法在钛种植体表面涂覆一层羟基磷灰石。将涂覆和未涂覆的钛板分别放入含有成纤维细胞的培养液中。将有涂层和无涂层的种植体螺钉分别植入兔骨中，分别在7、27和122天后安乐死动物。细胞培养试验结果显示，标本之间没有明显差异。种植体标本的组织学检查显示，在27天时，相对于涂层螺钉有更多的新骨活动，这在127天时更加明显。虽然新骨形成量没有显著差异，但与非涂层对照相比，涂层植入物接触时可以看到某些有利的新骨形成迹象。
Titanium implants were coated with hydroxyapatite by using a method of ion beam dynamic mixing. Coated and noncoated plates of titanium were placed in a growth medium with fibroblast cells. Implant screws, coated and noncoated, were inserted in rabbit bones and the animals were euthanized after 7, 27, and 122 days, respectively. The results from the cell culture test showed no visible difference between the specimens. Histologic examination of implant specimens indicated more new bone activity against coated screws at 27 days, and that was more pronounced at 127 days. Although the amount of new bone formation was not significantly different, certain signs of favourable new bone formation could be seen in contact with coated implants compared to the noncoated controls.