Development of cortical GABAergic circuits and its implications for neurodevelopmental disorders
Development of cortical GABAergic circuits and its implications for neurodevelopmental disorders
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DOI：
10.1111/j.1399-0004.2007.00822.x
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发表时间：
2007-07-01
影响因子：
3.5
通讯作者：
Di Cristo, G.
中科院分区：
文献类型：
--
作者：
Di Cristo, G.
GABA 能中间神经元强有力地控制皮质网络的功能。此外，它们通过调节神经元增殖、迁移、分化和连接等多种细胞过程来强烈调节皮质发育。毫不奇怪，GABA能回路的异常发育与许多神经发育障碍有关，包括精神分裂症、自闭症和抽动秽语综合征。不幸的是，GABA能中间神经元在形态和功能水平上的显着异质性损害了理解GABA能回路形成和功能调节机制的努力。最近的技术进步，包括中间神经元特异性标记技术的改进，已经开始揭示这一过程的基本原理。这篇综述总结了关于皮质中 GABA 能回路构建机制的最新发现，特别关注对神经发育起源的脑部疾病的潜在影响。
GABAergic interneurons powerfully control the function of cortical networks. In addition, they strongly regulate cortical development by modulating several cellular processes such as neuronal proliferation, migration, differentiation and connectivity. Not surprisingly, aberrant development of GABAergic circuits has been implicated in many neurodevelopmental disorders including schizophrenia, autism and Tourette's syndrome. Unfortunately, efforts directed towards the comprehension of the mechanisms regulating GABAergic circuits formation and function have been impaired by the strikingly heterogeneity, both at the morphological and functional level, of GABAergic interneurons. Recent technical advances, including the improvement of interneurons-specific labelling techniques, have started to reveal the basic principles underlying this process. This review summarizes recent findings on the mechanisms underlying the construction of GABAergic circuits in the cortex, with a particular focus on potential implications for brain diseases with neurodevelopmental origin.