Accelerated reoxygenation of a murine fibrosarcoma after carbon-ion radiation
Accelerated reoxygenation of a murine fibrosarcoma after carbon-ion radiation
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DOI：
10.1080/095530099140438
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发表时间：
1999-04-01
影响因子：
2.6
通讯作者：
Urano, M
中科院分区：
文献类型：
--
作者：
Ando, K;Koike, S;Urano, M
目的：用碳离子照射后的小鼠肿瘤的复氧进行了研究，并比较后gamma-ray.Materials和方法：NFSa纤维肉瘤细胞移植到同系C3 H雄性小鼠的右后腿。用290 MeV/u碳离子或137-Cs γ射线的条件照射被递送到直径为8 mm的肿瘤。在照射后的特定时间，腿部肿瘤（无论是否夹紧）都会接受测试剂量的光子。在肿瘤生长延迟之间的差异的钳和非钳肿瘤解释的复氧。采用肺集落试验获得细胞存活曲线。结果：74 keV μ m（-1）碳离子在NFSa肿瘤中的氧增强比为1.6，而γ射线的氧增强比为3.4。NFSa肿瘤在30戈伊的γ射线照射后4天复氧，但早在16戈伊的碳离子照射后1天复氧。复氧后，γ射线缩短到1天时，肿瘤最初被夹紧的条件irradiation.Conclusions：存活的氧化细胞在NFSa肿瘤的分数是较大的照射后，与碳离子比与γ射线，导致加速复氧。
Purpose: Reoxygenation of a murine tumour after irradiation with carbon ions was investigated and compared to that after gamma-rays.Materials and methods: NFSa fibrosarcoma cells were transplanted into the right hind legs of syngeneic C3H male mice. Conditioning irradiation with either 290 MeV/u carbon ions or 137-Cs gamma-rays was delivered to the tumours at 8 mm diameter. At given times after irradiation the leg tumours, either clamped or not, received test doses of photons. Differences in tumour growth delay between the clamped and non-clamped tumours were interpreted in terms of reoxygenation. A lung-colony assay was used to obtain cell-survival curves.Results: The oxygen enhancement ratio in the NFSa tumour For 74keV mu m(-1) carbon ions was 1.6 while that for gamma-rays was 3.4. The NFSa tumours reoxygenated 4 days after 30 Gy of gamma-ray irradiation, but reoxygenated as early as 1 day after 16Gy of carbon ions. Reoxygenation after gamma-rays shortened to 1 day when the tumours were initially clamped for the conditioning irradiation.Conclusions: The fraction of surviving oxic cells in the NFSa tumours is larger after irradiation with carbon ions than with gamma-rays, resulting in accelerated reoxygenation.