Hemoglobin A1c and Mean Glucose in Patients With Type 1 Diabetes Analysis of data from the Juvenile Diabetes Research Foundation continuous glucose monitoring randomized trial
Hemoglobin A1c and Mean Glucose in Patients With Type 1 Diabetes Analysis of data from the Juvenile Diabetes Research Foundation continuous glucose monitoring randomized trial
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DOI：
10.2337/dc10-1054
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发表时间：
2011-03-01
期刊：
影响因子：
16.2
通讯作者：
Tamborlane, William V.
中科院分区：
文献类型：
--
作者：
Wilson, Darrell M.;Xing, Dongyuan;Tamborlane, William V.
目的 确定明尼苏达大学糖尿病控制和并发症试验/糖尿病干预和并发症流行病学实验室在青少年糖尿病研究基金会连续血糖监测随机试验的 1 型糖尿病受试者队列中测量的平均传感器葡萄糖浓度与血红蛋白 A(1c) (HbA(1c)) 值之间的关系。 研究设计和方法 近连续葡萄糖传感器数据 (>=中心实验室对 252 名 8-74 岁受试者进行 HbA(1c) 测量，为期 3 个月，其中大多数人具有稳定的 HbA(1c) 值（77% 在患者平均值的 +/- 0.4% 范围内）。 结果 平均传感器葡萄糖浓度（曲线下面积）与中心测量的 HbA(1c) 的斜率 (95% Cl) 为 24.4 mg/dL HbA(1c) 每变化 1%，结果为 (22.0-26.7)，截距为 -16.2 mg/dL（-32.9 至 0.6）。尽管斜率不随年龄或性别而变化，但存在很大的个体差异，平均传感器葡萄糖浓度范围为 128 至 187 mg/dL，HbA(1c) 为 6.9-7.1%。实际平均传感器葡萄糖浓度与使用回归方程计算的值之间的误差均方根为 14.3 mg/dL，而中位绝对差为 10.1 mg/dL。 结论 测量的平均葡萄糖浓度与计算的平均葡萄糖浓度之间存在很大的个体差异。因此，应谨慎使用根据测量的 HbA(1c) 值计算出的估计平均葡萄糖浓度。糖尿病护理 34:540-544, 2011
OBJECTIVE To determine the relationship between mean sensor glucose concentrations and hemoglobin A(1c) (HbA(1c)) values measured in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications laboratory at the University of Minnesota in a cohort of subjects with type 1 diabetes from the Juvenile Diabetes Research Foundation continuous glucose monitoring randomized trial.RESEARCH DESIGN AND METHODS Near-continuous glucose sensor data (>= 4 days/week) were collected for 3 months before a central laboratory measured HbA(1c) was performed for 252 subjects aged 8-74 years, the majority of whom had stable HbA(1c) values (77% within +/- 0.4% of the patient mean).RESULTS The slope (95% Cl) for mean sensor glucose concentration (area under the curve) versus a centrally measured HbA(1c) was 24.4 mg/dL (22.0-26.7) for each 1% change in HbA(1c), with an intercept of -16.2 mg/dL (-32.9 to 0.6). Although the slope did not vary with age or sex, there was substantial individual variability, with mean sensor glucose concentrations ranging from 128 to 187 mg/dL for an HbA(1c) of 6.9-7.1%. The root mean square of the errors between the actual mean sensor glucose concentration versus the value calculated using the regression equation was 14.3 mg/dL, whereas the median absolute difference was 10.1 mg/dL.CONCLUSIONS There is substantial individual variability between the measured versus calculated mean glucose concentrations. Consequently, estimated average glucose concentrations calculated from measured HbA(1c) values should be used with caution. Diabetes Care 34:540-544, 2011