Bile Acids Affect the Growth of Human Cholangiocarcinoma via NF-kB Pathway
Bile Acids Affect the Growth of Human Cholangiocarcinoma via NF-kB Pathway
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DOI：
10.3109/07357907.2012.762781
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发表时间：
2013-02-01
影响因子：
2.4
通讯作者：
Wang, Jian
中科院分区：
文献类型：
--
作者：
Dai, Jiaqi;Wang, Hongxia;Wang, Jian
我们观察到游离胆汁酸（CA、DCA 和 CDCA）通过促进细胞凋亡来抑制胆管癌细胞的生长，而结合胆汁酸（GCA、GDCA 和 GCDCA）则刺激细胞生长。一致地，我们发现 GDCA 刺激异种移植小鼠的肿瘤生长，CDCA 减少肿瘤生长。此外，磷酸化的 IkB 被游离胆汁酸下调，并被结合胆汁酸上调。 IL-6 和 COX-2 因游离胆汁酸而减少，因结合胆汁酸而增加。总的来说，这些结果表明胆汁酸通过调节 NF-kB 通路来调节胆管癌的生长。
We observed that free bile acids (CA, DCA, and CDCA) inhibited the growth of cholangiocarcinoma cells by promoting cell apoptosis, while the conjugated bile acids (GCA, GDCA, and GCDCA) stimulated cell growth. Consistently, we found that GDCA stimulated tumor growth and CDCA decreased tumor growth in xenografted mice. Further, the phosphorylated IkB was downregulated by free bile acids, and was upregulated by the conjugated bile acids. IL-6 and COX-2 were decreased by the free bile acids and increased by the conjugated bile acids. Collectively, these results suggest that the bile acids regulate the growth of cholangiocarcinoma by modulating NF-kB pathway.