A frequency and correlation analysis of motor deficits in Parkinson patients
A frequency and correlation analysis of motor deficits in Parkinson patients
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DOI：
10.3109/09638289809166074
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发表时间：
1998-04-01
影响因子：
2.2
通讯作者：
Lesaffre, E
中科院分区：
文献类型：
--
作者：
Nieuwboer, A;De Weerdt, W;Lesaffre, E
目的：本研究探讨了一组帕金森病患者的功能性运动问题的频率和模式，作为制定合理的康复干预方法解决疾病主要症状的第一步。方法：60名患者，包括40%的女性和60%的男性，平均年龄为63.5岁，其中88%服用左旋多巴，进行了一些标准化的临床测试，包括第三部分的EURRS。他们还接受了采访的频率发生在home.Results：躯干旋转的损失表示在仰卧和减少手臂摆动滚动运动障碍（73%，75%）是最常见的注册。在临床试验期间未观察到行走开始时或行走过程中的冻结，但经常声称在家中发生（48%，23%）。有关步态、姿势、转移和远端运动问题的广泛缺陷形成一簇，与运动迟缓密切相关（p < 0.001）。主成分分析确定了四个不同的问题领域：（1）轴向运动性能;（2）运动不能步态问题;（3）刚性;（4）tremer.Conclusions：帕金森患者，特别是在疾病的后期阶段，提出了显着水平的功能障碍，这主要是与潜在的损害运动迟缓。
Purpose : The present study explored the frequency and pattern of functional motor problems of a group of Parkinson patients, as a first step towards developing a rational approach to rehabilitation intervention addressing the primary symptoms of the disease.Method: Sixty patients, consisting of 40 % women and 60 % men with a mean age of 63.5 years and of which 88 % were taking L-dopa, underwent a number of standardized clinical tests including part III of the UPDRS. They were also interviewed about the frequency of motor problems occurring at home.Results: Loss of trunk rotation as expressed in rolling in supine and reduced arm swing were the most frequently registered motor disorders (73 %, 75 %). Freezing at the start of, or during, walking was not observed during clinical testing but was frequently claimed to occur at home (48 %, 23 %). A broad spectrum of deficits regarding gait, posture, transfers and distal motor problems formed a cluster, which was strongly correlated with bradykinesia (p < 0.001). Principal component analysis identified four distinct problem areas: (1) axial motor performance; (2) akinetic gait problems; (3) rigidity; and (4) tremor.Conclusions: Parkinson patients, particularly in the later stages of the disease, presented with significant levels of functional disability which was mainly linked with the underlying impairment of bradykinesia.