Is there a special relationship between complex I activity and nigral neuronal loss in Parkinson's disease? A critical reappraisal.
Is there a special relationship between complex I activity and nigral neuronal loss in Parkinson's disease? A critical reappraisal.
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DOI：
10.1016/j.brainres.2021.147434
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发表时间：
2021-09-15
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
Parkinson’s disease (PD) is a progressive neurodegenerative disease manifesting both motor and non-motor symptoms. The motor features are generally ascribed to the selective loss of dopamine neurons within the substantia nigra pars compacta. While the precise etiology of PD remains elusive, multiple genetic and environmental elements have emerged as contributing factors. The discovery of MPTP-induced parkinsonism directed intense inquiry towards mitochondrial pathways, with a specific focus on mitochondrial complex I. Consisting of more than 40 subunits, complex I is the first enzyme of the electron transport chain that is required for mitochondrial ATP production. In this review, we present a critical analysis of studies assessing the prevalence and specificity of mitochondrial complex I deficiency in PD. In addition, we take the novel view of incorporating the features of genetically-defined bona fide complex I disorders and the prevalence of nigral involvement in such cases. Through this innovative bi-directional view, we consider both complex I changes in a disease of the substantia nigra and nigral changes in diseases of complex I. We assess the strength of association between nigral cell loss and complex I deficits, as well as the oft under-appreciated heterogeneity of complex I deficiency disorders and the variability of the PD data.
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影响因子：
4.3
作者：
Adjobo-Hermans, Merel J. W.;de Haas, Ria;Koopman, Werner J. H.
通讯作者：
Koopman, Werner J. H.
影响因子：
3.9
作者：
Bénit, P;Beugnot, R;Munnich, A
通讯作者：
Munnich, A
影响因子：
11
作者：
ANDERSON, JJ;BRAVI, D;DAGANI, F
通讯作者：
DAGANI, F
影响因子：
3.8
作者：
Barghuti, Flora;Elian, Khaled;Elpeleg, Orly
通讯作者：
Elpeleg, Orly
DOI：
10.1016/j.bbadis.2014.05.008
发表时间：
2014-09-01
影响因子：
6.2
作者：
Ambrosi, Giulia;Ghezzi, Cristina;Blandini, Fabio
通讯作者：
Blandini, Fabio