CompVision: An open-source five-compartmental software for biokinetic simulations
CompVision: An open-source five-compartmental software for biokinetic simulations
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DOI：
10.1515/phys-2021-0055
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发表时间：
2021-08-06
期刊：
影响因子：
1.9
通讯作者：
Yu, Kwan Ngok
中科院分区：
文献类型：
--
作者：
Beni, Mehrdad Shahmohammadi;Watabe, Hiroshi;Yu, Kwan Ngok
物理问题的模拟和数值分析是理解过程的基本机制的重要步骤。重要的例子是医学物理学和医学成像。考虑到不同的器官将被建模为隔室，已经发现隔室建模对于估计药物/污染物（通常用于医学物理和医学成像）在不同器官中的运输和时间变化是有用的。在这些模型化的隔室之间再循环（即，器官）是通过定义一组恒定的转移速率来允许的。为了在数学上定义这些系统，需要使用微分方程组（取决于隔室的数量），这实际上是耗时的，并且容易出现数学错误。考虑到这些问题，需要一个通用的计算机程序，是准确的，强大的，用户友好的自动执行所需的计算。在目前的工作中，我们开发了一个开源的计算机程序，名为CompVision，能够模拟五房室系统和基准。本软件为用户提供了一个易于使用的图形用户界面（GUI）。可执行程序和源代码在GPL v3许可下公开，允许每个人不受任何限制地使用，修改和分发。本程序将是有用的，在各种研究领域和应用。
Simulations and numerical analysis of physical problems are important steps toward understanding underlying mechanisms of the processes. Important exam-ples would be medical physics and medical imaging. Compartmental modeling has been found useful for esti-mating the transport and temporal variations of drugs/ contaminants (commonly used in medical physics and medical imaging) in different organs, given that different organs would be modeled as compartments. Recycling among these modeled compartments (i.e., organs) was allowed through defining sets of constant transfer rates. In order to mathematically define these systems, one needs to use sets of differential equations (depending on the number of compartments) which would in fact be time-consuming and prone to mathematical error. Considering these issues, there is a need for a versatile computer pro-gram that is accurate, robust, and user-friendly to perform the required computations automatically. In the present work, we developed and benchmarked an open-source computer program entitled CompVision that was able to simulate five-compartmental systems. The present soft-ware had an easy-to-use graphical user interface (GUI) for the users. The executable program and the source codes were made available publicly under GPLv3 license, which would allow everyone to use, modify, and distribute without any restriction. The present program would be useful in a variety of research fields and applications.