Unrecognized Viral Respiratory Tract Infections in Premature Infants during their Birth Hospitalization: A Prospective Surveillance Study in Two Neonatal Intensive Care Units
Unrecognized Viral Respiratory Tract Infections in Premature Infants during their Birth Hospitalization: A Prospective Surveillance Study in Two Neonatal Intensive Care Units
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DOI：
10.1016/j.jpeds.2012.05.001
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发表时间：
2012-11-01
影响因子：
5.1
通讯作者：
Domachowske, Joseph B.
中科院分区：
文献类型：
--
作者：
Bennett, Nicholas J.;Tabarani, Christy M.;Domachowske, Joseph B.
目的了解新生儿院内呼吸道病毒感染（RVIs）的发生频率及影响，包括无症状早产儿。研究设计我们对2个锡拉丘兹新生儿重症监护室收治的小于33周胎龄的婴儿进行了为期一年的RVIs监测。婴儿在新生儿重症监护病房入院3天内入组，使用多重聚合酶链反应法检测17种不同呼吸道病毒或亚型，直至出院。结果50例早产儿中有26例（52%）在出生住院期间至少一次检测出呼吸道病毒阳性。呼吸道病毒检测呈阳性与住院时间延长（70天vs 35天，P = 0.002）和延长呼吸支持时间（51天vs 13天，P = 0.002）显著相关。出生住院期间呼吸道病毒检测呈阳性的婴儿发生支气管肺发育不良的比率是前者的两倍多（P < 0.05）。结论在我们的研究人群中，尽管缺乏疾病的临床指标，但医院RVIs是常见的。住院时间明显更长，支气管肺发育不良的诊断在检测到呼吸道病毒的婴儿中更为常见。[J] .中华儿科杂志；2012;31(1):814- 818。
Objective To determine the frequency and effects of nosocomial respiratory viral infections (RVIs) in premature neonates, including those who may be asymptomatic.Study design We performed a year-long surveillance for RVIs in infants < 33 weeks gestational age admitted to 2 Syracuse neonatal intensive care units. Infants were enrolled within 3 days of neonatal intensive care unit admission and were sampled for RVIs until discharge using a multiplex polymerase chain reaction assay capable of detecting 17 different respiratory viruses or subtypes.Results Twenty-six of 50 prematurely born infants (52%) tested positive for a respiratory virus at least once during their birth hospitalization. Testing positive for a respiratory virus was significantly associated with longer length of stay (70 days vs 35 days, P = .002) and prolonged ventilatory support (51 vs 13 days, P = .002). Infants who tested positive for a respiratory virus during their birth hospitalization had more than twice the rate of developing bronchopulmonary dysplasia (P < .05).Conclusion Nosocomial RVIs were frequent in our study population, despite the absence of clinical indicators of illness. Length of hospital stay was significantly longer and a diagnosis of bronchopulmonary dysplasia was more common in infants who had respiratory viruses detected. (J Pediatr 2012;161:814-8).