Cannabinoid receptor 1 gene association with nicotine dependence
Cannabinoid receptor 1 gene association with nicotine dependence
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DOI：
10.1001/archpsyc.65.7.816
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发表时间：
2008-07-01
影响因子：
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通讯作者：
Kendler, Kenneth S.
中科院分区：
文献类型：
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作者：
Chen, Xiangning;Williamson, Vernell S.;Kendler, Kenneth S.
背景：内源性大麻素系统与动物模型中的药物成瘾有关。大麻素受体1（CNR 1）基因是大脑中表达的两种受体之一。目的：验证CNR 1基因与尼古丁依赖相关的假设。设计：基因型-表型关联研究。10个单核苷酸多态性基因分型CNR 1基因在2个独立的样本。对于第一个样本（n=688），使用3组病例对照设计来测试等位基因与吸烟开始和尼古丁依赖的关联。对于第二个样本（n=961），用Fagerstrom尼古丁依赖性测试（FTND）的评分评估相关性。设置：从大西洋中部双胞胎登记处选择的人群样本。参与者：符合入选标准的18至65岁的白色患者。主要结果测量：Fagerstrom耐受性问卷和FTND评分。结果：在这两个样本中发现了显着的单标记和单倍型协会，协会是女性特有的。在2个样本中，rs 2023239-rs 12720071-rs 806368单倍型1-1-2与尼古丁依赖和FTND评分相关（P
Context: The endogenous cannabinoid system has been implicated in drug addiction in animal models. The cannabinoid receptor 1( CNR1) gene is 1 of the 2 receptors expressed in the brain. It has been reported to be associated with alcoholism and multiple drug abuse and dependence.Objective: To test the hypothesis that the CNR1 gene is associated with nicotine dependence.Design: Genotype-phenotype association study. Ten single-nucleotide polymorphisms were genotyped in the CNR1 gene in 2 independent samples. For the first sample (n=688), a 3-group case-control design was used to test allele association with smoking initiation and nicotine dependence. For the second sample (n=961), association was assessed with scores from the Fagerstrom Test for Nicotine Dependence (FTND).Settings: Population samples selected from the Mid-Atlantic Twin Registry.Participants: White patients aged 18 to 65 years who met the criteria of inclusion.Main Outcome Measures: Fagerstrom Tolerance Questionnaire and FTND scores.Results: Significant single-marker and haplotype associations were found in both samples, and the associations were female specific. Haplotype 1-1-2 of markers rs2023239-rs12720071-rs806368 was associated with nicotine dependence and FTND score in the 2 samples ( P