Epstein-Barr virus-associated gastric adenocarcinoma among Japanese Americans in Hawaii.
Epstein-Barr virus-associated gastric adenocarcinoma among Japanese Americans in Hawaii.
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发表时间：
1993-05
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通讯作者：
Darryl Shibata;Debra Hawes;Grant N. Stemmermann;Weiss Lm
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作者：
Darryl Shibata;Debra Hawes;Grant N. Stemmermann;Weiss Lm
本研究证实了部分胃腺癌癌细胞中含有eb病毒（EBV）序列。应用聚合酶链反应和原位杂交技术，在夏威夷187例日裔美国人中19例（10.2%）的肿瘤中检测到EBV序列。ebv相关胃癌在男性中的发生率高于女性：99例男性中有14例（14.3%），88例女性中有5例（5.7%）（P = 0.046）。在19例EBV相关癌症中有17例发现了EBV A型，这一发现与日本人群中A型的优势一致。肠型和弥漫性肿瘤均为ebv阳性，通常存在中度至明显的炎症。在邻近的正常非肿瘤性粘膜细胞或肠化生粘膜中未发现病毒。与ebv阴性肿瘤的36%相比，53%的病例在1期或2期发现ebv相关肿瘤（P = 0.13）。EBV的存在似乎不影响生存。与其他ebv相关肿瘤相比，胃癌的发病率相对较高，使得ebv相关胃癌可能成为美国最常见的ebv相关肿瘤之一。
This study confirms the observation that some gastric adenocarcinomas contain Epstein-Barr viral (EBV) sequences in their carcinoma cells. EBV sequences were detected by polymerase chain reaction and in situ hybridization in the tumors of 19 of 187 (10.2%) Japanese-American men and women living in Hawaii. The EBV-associated gastric cancers were more frequently present in men than in women: 14 of 99 (14.3%) men versus 5 of 88 (5.7%) women (P = 0.046). EBV type A was found in 17 of the 19 EBV-associated cancers, a finding consistent with the type A predominance in Japanese populations. Intestinal and diffuse-type tumors were both EBV-positive, and moderate to marked inflammation was usually present. The virus was not found in adjacent normal nonneoplastic mucosal cells or in mucosa showing intestinal metaplasia. EBV-associated tumors were found at stages 1 or 2 in 53% of cases, compared with 36% of the EBV-negative cancers (P = 0.13). The presence of EBV did not appear to influence survival. The relatively high incidence of gastric cancer compared to other EBV-associated tumors makes EBV-associated gastric cancer potentially one of the most common EBV-related tumors in the United States.