Glomerular lysozyme binding in protein-overload proteinuria
Glomerular lysozyme binding in protein-overload proteinuria
复制标题
蛋白质超载蛋白尿中的肾小球溶菌酶结合
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
D. Brewer
中科院分区：
文献类型：
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作者：
D. Bliss;D. Brewer
在正常雌性Wistar大鼠肾小球和每日灌服1g牛血清白蛋白诱发重度蛋白尿的大鼠肾小球中，观察了阳离子分子溶菌酶与肾小球基底膜和肾小球上皮细胞膜的结合。在正常大鼠，溶菌酶与肾小球基底膜和细胞膜上的阴离子基团的结合对肾小球上皮细胞的超微结构没有影响，尤其是足突没有改变。在蛋白尿症大鼠，溶菌酶与肾小球基底膜和上皮细胞的结合在受损的肾小球中完全消失。在这些蛋白尿动物的明显正常的肾小球中，结合与正常大鼠相似。这些结果表明，在蛋白超负荷蛋白尿中，肾小球阴离子丢失，因此肾小球电荷屏障减少。这可能至少部分解释了在这个蛋白尿的实验模型中，肾小球负电荷血清白蛋白渗漏增加的原因。
SummaryBinding of the cationic molecule lysozyme to the glomerular basement membrane and to the glomerular epithelial cell coat was investigated in the glomerulus of normal female Wistar rats and in rats in which heavy proteinuria was induced by the daily administration of 1 g of bovine serum albumin.In normal rats the binding of lysozyme to the anionic groups in the glomerular basement membrane and the cell coat had no effect on the ultrastructure of the glomerular epithelial cell, in particular the foot processes were unchanged.In the proteinuric rats the lysozyme-binding to the glomerular basement membrane and the epithelial cell coat was completely lost in the damaged glomeruli. In the apparently normal glomeruli present in these proteinuric animals binding was similar to that seen in normal rats.These results suggest that in protein-overload proteinuria there is a loss of glomerular anion and hence a reduction in the glomerular charge barrier. This may account, at least in part, for the increased glomerular leak of negatively charged serum albumin in this experimental model of proteinuria.
大鼠氨基核苷肾病肾小球滤过器电荷和尺寸选择性屏障的变化。
DOI：
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发表时间：
1981
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
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作者：
Olson,JL;Rennke,HG;Venkatachalam,MA
通讯作者：
Venkatachalam,MA