The relationship of serum triglycerides, serum HDL, and obesity to the risk of wheezing in 85,555 adults
The relationship of serum triglycerides, serum HDL, and obesity to the risk of wheezing in 85,555 adults
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DOI：
10.1016/j.rmed.2013.02.001
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发表时间：
2013-06-01
影响因子：
4.3
通讯作者：
Calvo, E.
中科院分区：
文献类型：
--
作者：
Fenger, R. V.;Gonzalez-Quintela, A.;Calvo, E.
背景资料：哮喘与肥胖和代谢综合征的存在有关。目的：探讨代谢综合征中哪些成分与哮喘的主要症状喘息相关。此外，探讨这些协会是否有不同的个人和没有鼻炎symptoms.Methods：我们使用的数据从Ibermutuamur心血管风险评估计划（ICARIA），包括85,555西班牙工人（中位年龄= 34，范围= 16-75岁）与自我报告的喘息和鼻炎症状的评估。结果：在包括代谢综合征各组分和可能的混杂因素的相互校正分析中，WC（或BMI）升高、s-TG升高和s-HDL降低与喘息显著相关。比值比（OR）及可信区间（CI）为：WC升高= 1.54（1.46-1.62），s-TG升高= 1.24（1.18-1.30），s-HDL降低= 1.17（1.12-1.22）。这些关联在没有鼻炎症状的个体中比在有鼻炎症状的个体中更强，OR（CI）为WC =没有鼻炎1.70（1.57-1.85）vs.有鼻炎1.47（1.37-1.58）。s-TG升高=无鼻炎1.36（1.26-1.46）vs有鼻炎1.21（1.13-1.29）。低s-HDL =无鼻炎组1.24（1.15-1.34）vs有鼻炎组1.11（1.04-1.18）。结论：调整肥胖后，高s-TG和低s-HDL与喘息相关。这可以证实升高的s-TG和降低的s-HDL作为炎症相关疾病的标志物或诱导物。这项研究支持了这样一种观点，即这些生化标志物对不同类型的喘息有不同的影响。(c)2013爱思唯尔有限公司保留所有权利。
Background: Asthma has been linked to obesity and the presence of the metabolic syndrome.Objective: To explore which components of the metabolic syndrome that were associated with wheezing, a main symptom of asthma. Further, to explore whether these associations were different in individuals with and without rhinitis symptoms.Methods: We used data from the Ibermutuamur Cardiovascular Risk Assessment Plan (ICARIA) including 85,555 Spanish workers (median age = 34, range = 16-75 years) with assessments of self reported wheezing and rhinitis symptoms. Fasting blood samples were analysed for serum triglyceride (s-TG), HDL (s-HDL) and glucose; blood pressure, waist circumference (WC) and body mass index (BMI) were measured.Results: In mutually adjusted analyses including all components of the metabolic syndrome and possible confounders, elevated WC (or BMI), elevated s-TG and low s-HDL were significantly associated with wheezing. Odds ratio (OR) with confidence interval (CI) were: elevated WC = 1.54 (1.46-1.62), elevated s-TG = 1.24 (1.18-1.30), low s-HDL = 1.17 (1.12-1.22). These associations were stronger in individuals without than in those with rhinitis symptoms, OR's (CI's) were WC = without rhinitis 1.70 (1.57-1.85) vs. with rhinitis 1.47 (1.37-1.58). Elevated s-TG = without rhinitis 1.36 (1.26-1.46) vs. with rhinitis 1.21 (1.13-1.29). Low s-HDL = without rhinitis 1.24 (1.15-1.34) vs. with rhinitis 1.11 (1.04-1.18).Conclusions: High s-TG and low s-HDL were associated with wheezing after adjustment for adiposity. This may substantiate elevated s-TG and lowered s-HDL as markers or inducers of inflammation associated disease. The study supports the notion that these biochemical markers have differential effects on different types of wheezing. (c) 2013 Elsevier Ltd. All rights reserved.