Central Hemodynamic Effects of Cocaine and Ritodrine in the Isolated, Perfused Rat Heart
Central Hemodynamic Effects of Cocaine and Ritodrine in the Isolated, Perfused Rat Heart
复制标题
可卡因和利托君对离体灌注大鼠心脏的中枢血流动力学影响
作者：
J. Kurtzman;J. Thorp;F. Spielman;R. Mueller;R. Cefalo
目的：探讨妊娠期可卡因和利托君对心脏的相互作用。研究方法：使用离体灌注大鼠心脏模型，将妊娠Sprague-Dawley大鼠的心脏暴露于递增浓度的利托君：25、50、100和250 ng/mL。实验组动物心脏暴露于可卡因（5 × 10-6 mol/L）。测量左心室收缩压、心率和收缩力。结果：利托君具有明显的正性肌力和变时作用。暴露于可卡因导致所有指数的增加较小。结论：在该模型中，胆固醇减弱但不消除利托君的心脏刺激作用。
Objective: To explore the cardiac interactions of cocaine and ritodrine in pregnancy. Methods: Using the isolated, perfused rat-heart model, hearts from pregnant Sprague-Dawley rats were exposed to increasing concentrations of ritodrine: 25, 50,100, and 250 ng/mL. Hearts of half of the animals, the experimental group, were exposed to cocaine (5 × 10-6 mol/L). Left ventricular systolic pressure, heart rate, and contractility were measured. Results: Ritodrine had marked positive inotropic and chronotropic effects. Cocaine exposure resulted in smaller increases in all indices. Conclusion: Cocaine blunted but did not obliterate the cardiac stimulatory effects of ritodrine in this model.