Risk Factors for Cytarabine-Induced Cutaneous Toxicity in Patients with Haematological Malignancies.
Risk Factors for Cytarabine-Induced Cutaneous Toxicity in Patients with Haematological Malignancies.
复制标题
血液恶性肿瘤患者阿糖胞苷引起的皮肤毒性的危险因素。
DOI：
10.1159/000371839
复制
发表时间：
2015
期刊：
影响因子：
3.3
通讯作者：
Uejima E.
中科院分区：
文献类型：
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作者：
Morio K;Mizuki M;Sozu T;Uejima E.
背景：阿糖胞苷（Ara-C）诱导的皮肤毒性的危险因素尚不清楚。方法：我们回顾性地审查了与Ara-C治疗的造血系统恶性肿瘤患者的病历，并检查Ara-C诱导的皮肤毒性的危险因素。结果：我们回顾了114例（76名男性，38名女性），发现47例（41.2%）经历了皮肤毒性。93例（81.6%）的非霍奇金淋巴瘤（NHL）和急性髓性白血病（AML）患者，毒性与癌症类型[AML/NHL：比值比（OR）= 4.84; 95%置信区间（CI）= 1.99-11.81; p = 0.001]、年龄显著相关。（<50/≥50岁：OR = 2.54; 95% CI = 1.08-5.95; p = 0.032）和同时使用类固醇（是/否：OR = 0.22; 95% CI = 0.09-0.56; p = 0.001）。结论：急性髓细胞白血病、年龄<50岁、未使用激素是阿糖胞苷皮肤毒性的危险因素。
Background:The risk factors for cytarabine (Ara-C)-induced cutaneous toxicity are unclear.Methods:We retrospectively reviewed the medical charts of patients with haematopoietic malignancies treated with Ara-C and examined risk factors for Ara-C-induced cutaneous toxicity.Results:We reviewed 114 patients (76 men, 38 women) and found that 47 patients (41.2%) experienced cutaneous toxicity. In 93 patients (81.6%) with non-Hodgkin's lymphoma (NHL) and acute myeloid leukaemia (AML), the toxicity was significantly associated with the cancer type [AML/NHL: odds ratio (OR) = 4.84; 95% confidence interval (CI) = 1.99-11.81; p = 0.001], age (<50/≥50 years: OR = 2.54; 95% CI = 1.08-5.95; p = 0.032) and concurrent steroid administration (yes/no: OR = 0.22; 95% CI = 0.09-0.56; p = 0.001). AML was the only significant association (OR = 3.83; 95% CI = 1.21-12.06; p = 0.022) in the multivariate logistic analysis.Conclusion:AML, age <50 years and no steroid use are considered to be risk factors for Ara-C-induced cutaneous toxicity.